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Definition

By Mayo Clinic staff

Gangrene refers to the death of body tissue due to a lack of blood flow or a bacterial infection. Gangrene most commonly affects the extremities, including your toes, fingers and limbs, but it can also occur in your muscles and internal organs.

Your chances of developing gangrene are higher if you have an underlying condition that can damage your blood vessels and affect blood flow, such as diabetes or atherosclerosis.

Treatments for gangrene include surgery to remove dead tissue, antibiotics and other approaches. The prognosis for recovery is better if gangrene is identified early and treated quickly.

Symptoms
References
  1. Neschis DG, et al. Clinical manifestations and evaluation of chronic critical limb ischemia. http://www.uptodate.com/home/index/html. Accessed May 16, 2011.
  2. Park H, et al. Complex wounds and their management. Surgical Clinics of North America. 2010;90:1181.
  3. Helviz Y, et al. Bad to worse. The American Journal of Medicine. 2011;124:215.
  4. Sepsis and septic shock. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/sec06/ch068/ch068a.html. Accessed May 15, 2011.
  5. Stevens DL, et al. Clostridial myonecrosis. http://www.uptodate.com/home/index.html. Accessed May 16, 2011.
  6. Gas gangrene. American Academy of Pediatrics. http://www.healthychildren.org/English/health-issues/conditions/skin/pages/Gas-Gangrene.aspx. Accessed May 16, 2011.
  7. Mechem C, et al. Frostbite. http://www.uptodate.com/home/index/html. Accessed May 15, 2011.
  8. Stevens DL. Necrotizing infections of the skin and fascia. http://www.uptodate.com/home/index/html. Accessed May 16, 2011.
  9. Intestinal obstruction. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merckmanuals.com/professional/print/sec02/ch011/ch011h.html. Accessed May 26, 2011.
  10. Mandell JE, et al. Necrotizing fasciitis, Fournier's gangrene In: Mandell JE, et al. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 7th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2010. http://www.mdconsult.com/books/page.do?sid=1163686964&eid=4-u1.0-B978-0-443-06839-3..00043-6--s0035&isbn=978-0-443-06839-3&uniqId=251414141-4. Accessed May 23, 2011.
  11. Mechem C, et al. Hyperbaric oxygen therapy. http://www.uptodate.com/home/index/html. Accessed May 20, 2011.
  12. Fujiwara Y, et al. Beneficial effects of foot care nursing for people with diabetes mellitus: An uncontrolled before and after intervention study. Journal of Advanced Nursing. In press. Accessed May 26, 2011.
  13. Saavedra A, et al. Soft-tissue infections: Erysipelas, cellulitis, gangrenous cellulitis, and myonecrosis. In: Wolff K, et al. Fitzpatrick's Dermatology in General Medicine. 7th ed. New York, N.Y.: The McGraw-Hill Companies; 2008. http://www.accessmedicine.com/content.aspx?aID=2995017&searchStr=gangrene#2995017. Accessed May 27, 2011.
  14. Coumadin (prescribing information). New York, N.Y.: Bristol-Myers Squibb; 2005. http://www.accessdata.fda.gov/drugsatfda_docs/label/2005/009218s101lbl.pdf. Accessed May 31, 2011.
DS00993 Aug. 10, 2011

© 1998-2013 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.com," "EmbodyHealth," "Enhance your life," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.

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