Generalized anxiety disorder

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Causes

By Mayo Clinic staff

As with many mental health conditions, what causes generalized anxiety disorder isn't fully understood. It may involve naturally occurring brain chemicals (neurotransmitters), such as serotonin, dopamine and norepinephrine. It's likely that the condition has several causes that may include genetics, your life experiences and stress.

Some physical health conditions are associated with anxiety. Examples include:

  • Gastroesophageal reflux disease (GERD)
  • Heart disease
  • Hypothyroidism or hyperthyroidism
  • Menopause
References
  1. Generalized anxiety disorder (includes overanxious anxiety disorder of childhood). In: Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR. 4th ed. Arlington, Va.: American Psychiatric Association; 2000. http://www.psychiatryonline.com. Accessed June 10, 2011.
  2. Schneier SR. Generalized anxiety disorder: Epidemiology, clinical manifestations, and diagnosis. http://www.uptodate.com/home/index.html. Accessed June 10, 2011.
  3. Blevins NC, et al. Anxiety disorders. In: Bope ET, et al. Conn's Current Therapy. Philadelphia, Pa.: Saunders Elsevier; 2011. http://www.mdconsult.com/books/page.do?eid=4-u1.0-B978-1-4377-0986-5..00011-9--sc9005&isbn=978-1-4377-0986-5&uniqId=257876576-3#4-u1.0-B978-1-4377-0986-5..00011-9--sc9005. Accessed June 10, 2011.
  4. Lee RA. Anxiety disorders. In: Rakel D. Integrative Medicine. 2nd ed. Philadelphia, Pa.: Saunders Elsevier; 2007. http://www.mdconsult.com/das/book/body/208746819-2/0/1494/0.html. Accessed June 10, 2011.
DS00502 Sept. 8, 2011

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