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Causes
By Mayo Clinic staffGilbert's syndrome is caused by an abnormal gene that you inherit from your parents. The gene controls an enzyme that helps break down bilirubin in your liver. With an ineffective gene, excess amounts of bilirubin build up in your blood.
How the body normally processes bilirubin
Bilirubin is a yellowish pigment that's made when your body breaks down old red blood cells. Bilirubin travels through your bloodstream to the liver. Normally an enzyme in liver cells breaks down the bilirubin and removes it from the bloodstream. The bilirubin passes from the liver into the intestines with bile. It's then excreted in stool. A small amount of bilirubin remains in the blood.
How the abnormal gene is passed through families
The abnormal gene that causes Gilbert's syndrome is common. Many people carry one copy of this abnormal gene. Two abnormal copies are needed to cause Gilbert's syndrome. If two people who each carry one copy of the abnormal gene have a child, they may pass along the genetic defect that causes Gilbert's syndrome.
- Berk PD, et al. Approach to the patient with jaundice or abnormal liver test results. In: Goldman L, et al. Cecil Medicine. 23rd ed. Philadelphia, Pa.: Saunders Elsevier; 2007. http://www.mdconsult.com/das/book/body/189880460-4/0/1492/0.html. Accessed March 18, 2010.
- Lidofsky SD. Jaundice. In: Feldman M, et al. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 8th ed. Philadelphia, Pa.: Saunders Elsevier; 2006. http://www.mdconsult.com/das/book/body/189880460-5/0/1389/0.html. Accessed March 18, 2010.
- Ferri FF. Gilbert's disease. In: Ferri FF. Ferri's Clinical Advisor 2010. Philadelphia, Pa.: Mosby; 2010. http://www.mdconsult.com/das/book/body/189880460-5/0/2088/0.html. Accessed March 18, 2010.
- Chowdhury NR, et al. Gilbert's syndrome and unconjugated hyperbilirubinemia due to bilirubin overproduction. http://www.uptodate.com. Accessed March 18, 2010.
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