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Causes
By Mayo Clinic staffGrand mal seizures occur when the electrical activity over the whole surface of the brain becomes abnormally synchronized. In general, seizures are caused by abnormal, rhythmic nerve cell (neuron) activity in the brain. The brain's nerve cells normally communicate with each other by sending electrical and chemical signals across the synapses that connect the cells. In people who have seizures, the brain's usual electrical activity is altered.
Exactly what causes the changes to occur remains unknown in about half of the cases. However, grand mal seizures are sometimes caused by underlying health problems, such as:
- Very low blood levels of glucose, sodium, calcium or magnesium
- Traumatic head injuries
- Using or withdrawing from drugs, including alcohol
- Brain tumors
- Strokes
- Infections, such as encephalitis or meningitis, or history of such infection
- Injury due to a previous lack of oxygen
- Blood vessel malformations in the brain
- Genetic syndromes
- Ropper AH, et al. Epilepsy and other seizure disorders. In: Ropper AH, et al. Adams and Victor's Principles of Neurology. 9th ed. New York, N.Y.: McGraw-Hill Medical Pub. Division; 2009. http://www.accessmedicine.com/content.aspx?aID=3632229. Accessed April 22, 2009.
- Seizures and epilepsy: Hope through research. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/epilepsy/detail_epilepsy.htm?css=print. Accessed April 24, 2009.
- Seizure disorders. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/print/sec16/ch214/ch214a.html. Accessed April 26, 2009.
- Stafstrom CE, et al. Pathophysiology of seizures and epilepsy. http://www.uptodate.com/index/home.html. Accessed April 17, 2009.
- Sheth RD. Epilepsy in infancy and childhood. In: Rakel RE, et al. Rakel & Bope: Conn's Current Therapy 2008. 60th ed. Philadelphia, Penn.: Saunders Elsevier; 2008. http://www.mdconsult.com/das/book/body/134947244-2/834264406/1621/460.html?printi. Accessed April 26, 2009.
- Elger CE. Modern management of epilepsy: A practical approach. Epilepsy and Behavior. 2008;12:501.
- Practice parameter update: Management issues for women with epilepsy - Focus on pregnancy (an evidence based review): Teratogenesis and perinatal outcomes. St. Paul, Minn.: American Academy of Neurology. http://www.neurology.org/cgi/content/abstract/WNL.0b013e3181a6b312v1. Accessed April 27, 2009.
- Britton JW (expert opinion). Mayo Clinic, Rochester, Minn. May 14, 2009.
