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Causes
By Mayo Clinic staff
The exact cause of Guillain-Barre syndrome is unknown. In about 60 percent of cases, an infection affecting either the lungs or the digestive tract precedes the disorder. But scientists don't know why such an infection can lead to Guillain-Barre syndrome for some people and not for others. Many cases appear to occur without any triggers.
In Guillain-Barre syndrome, your immune system — which usually only attacks foreign material and invading organisms — begins attacking the nerves that carry signals between your body and your brain. Specifically, the nerves' protective covering (myelin sheath) is damaged and this interferes with the signaling process, causing weakness, numbness or paralysis.
- Benatar M., et al. Guillain-Barre syndrome. In: Ferri FF. Ferri's Clinical Advisor 2009. St. Louis, Mo.: Mosby; 2008. http://www.mdconsult.com/das/book/body/130350733-11/0/1701/245.html. Accessed April 9, 2009.
- Guillain-Barre syndrome. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/gbs/detail_gbs.htm?css=print. Accessed April 7, 2009.
- Cruse RP. Overview of Guillain-Barre syndrome in children. http://www.uptodate.com/home/index.html. Accessed April 7, 2009.
- Vriesendorp FJ. Clinical features and diagnosis of Guillain-Barre syndrome in adults. http://www.uptodate.com/home/index.html. Accessed April 7, 2009.
- Shields RW, et al. Demyelinating disorders of the peripheral nervous system. In: Goetz GG. Textbook of Clinical Neurology. Philadelphia, Pa.: Saunders Elsevier; 2007. http://www.mdconsult.com/das/book/body/130350733-10/0/1488/410.html. Accessed April 7, 2009.
- Vriesendorp FJ. Treatment and prognosis of Guillain-Barre syndrome in adults. http://www.uptodate.com/home/index.html. Accessed April 7, 2009.
- Guillain-Barre syndrome (GBS). The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/sec16/ch223/ch223c.html?qt=guillain-barre&alt=sh . Accessed May 5, 2009.
- Seasonal flu and Guillain-Barre syndrome (GBS). Centers for Disease Control and Prevention. http://www.cdc.gov/FLU/about/qa/gbs.htm. Accessed May 5, 2009.
