Mayo Clinic Health Manager
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Get StartedSymptoms
Hand-foot-and-mouth disease may cause all of the following signs and symptoms or just some of them. They include:
- Fever
- Sore throat
- Feeling of being unwell (malaise)
- Painful, red, blister-like lesions on the tongue, gums and inside of the cheeks
- A red, nonitchy, possibly blistery rash on palms of the hands and soles of the feet, and sometimes the buttocks
- Irritability in infants and toddlers
- Loss of appetite
The usual period from initial infection to the onset of signs and symptoms (incubation period) is three to seven days. A fever is often the first sign of hand-foot-and-mouth disease, followed by a sore throat and sometimes a poor appetite and malaise. One or two days after the fever begins, painful sores may develop in the mouth or throat. A rash on the hands and feet and possibly on the buttocks can follow within one or two days.
When to see a doctor
Hand-foot-and-mouth disease is usually a minor illness causing only a few days of fever and relatively mild signs and symptoms. Contact your doctor, however, if mouth sores or a sore throat keep your child from drinking fluids. Contact your doctor also if after a few days, your child's signs and symptoms worsen.
- Hand, foot, & mouth disease (HFMD). Centers for Disease Control and Prevention. http://www.cdc.gov/ncidod/dvrd/revb/enterovirus/hfhf.htm. Accessed June 22, 2009.
- Enteroviruses - non polio. World Health Organization. http://www.who.int/mediacentre/factsheets/fs174/en/print.html. Accessed June 22, 2009.
- Hand, foot and mouth disease. American Osteopathic College of Dermatology. http://www.aocd.org/skin/dermatologic_diseases/hand_foot_mouth_disease.html. Accessed June 22, 2009.
- Non-polio enterovirus infections. Centers for Disease Control and Prevention. www.cdc.gov/ncidod/dvrd/revb/enterovirus/non-polio_entero.htm. Accessed June 26, 2009.