Hemolytic uremic syndrome (HUS)

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Definition

Hemolytic uremic syndrome (HUS) is an uncommon but serious condition that can cause life-threatening kidney failure, especially for children and older adults.

In children, most cases of hemolytic uremic syndrome develop after several days of diarrhea — often bloody — due to infection with a specific strain of Escherichia coli (E. coli) known as O157:H7. Adults also may develop hemolytic uremic syndrome after an E. coli infection, but more often the cause is obscure or even unknown.

E. coli refers to a group of bacteria normally found in the intestines of healthy humans and animals. Of the hundreds of types of E. coli, most are harmless. But a few strains of E. coli are responsible for serious food-borne infections, including those that can lead to hemolytic uremic syndrome. E. coli is most often found in unwashed produce or undercooked meat. E. coli may also be present in swimming pools or lakes contaminated with feces.

Simple precautions — such as washing and cooking foods adequately and avoiding unclean swimming areas — can help prevent infections that could lead to hemolytic uremic syndrome, especially for children and older adults.

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