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Complications
By Mayo Clinic staffFor most people, symptoms of Henoch-Schonlein purpura improve in a few weeks, leaving no lasting problems. Recurrences are fairly common, however. Children who have severe symptoms appear more likely to have a recurrence, but repeat bouts are usually milder than the initial episode.
In rare cases, Henoch-Schonlein purpura can cause a bowel obstruction (intussusception) that reduces blood flow to the intestinal tract and leads to inflammation of other organs, including the pancreas.
Kidney damage: A serious complication
The most serious complication of Henoch-Schonlein purpura is kidney damage, which can cause blood in the urine, swelling and high blood pressure. Most children with kidney problems recover fully, but in a small percentage of cases, Henoch-Schonlein purpura leads to end-stage kidney disease. In that case, dialysis or a kidney transplant may be needed.
The long-term outcome for people with Henoch-Schonlein purpura appears to depend on whether they develop kidney problems and how severe those problems are.
- Kraft DM, et al. Henoch-Schonlein purpura: A review. American Academy of Family Physicians. http://www.aafp.org/afp/980800ap/kraft.html. Accessed Aug. 10, 2008.
- Dedeoglu F, et al. Management of Henoch-Schonlein purpura. http://www.uptodate.com/home/index.html. Accessed Aug. 10, 2008.
- Dedeoglu F, et al. Clinical manifestations and diagnosis of Henoch-Schonlein purpura. http://www.uptodate.com/home/index.html. Aug. 17, 2008.
- Gibson KL, et al. Corticosteroid therapy for Henoch-Schonlein purpura. Pediatrics. 2008;121(4):870-871.
- Henoch-Schonlein purpura. Vasculitis Foundation. http://www.vasculitisfoundation.org/HenochSchonleinpurpura. Accessed Aug. 10, 2008.
- Weiss PF, et al. Effects of corticosteroid on Henoch-Schonlein purpura: A systematic review. Pediatrics. 2007;120(5):1079-1087.
- Henoch-Schonlein Purpura. National Kidney and Urologic Diseases Clearinghouse. http://kidney.niddk.nih.gov/kudiseases/pubs/HSP. Accessed Aug. 10, 2008.
