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Hepatitis CBy Mayo Clinic staff
Original Article: http://www.mayoclinic.com/health/hepatitis-c/DS00097
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Hepatitis C is an infection caused by a virus that attacks the liver and leads to inflammation. Most people infected with the hepatitis C virus (HCV) have no symptoms. In fact, most people don't know they have the hepatitis C infection until liver damage shows up, decades later, during routine medical tests.
Hepatitis C is one of several hepatitis viruses and is generally considered to be among the most serious of these viruses. Hepatitis C is passed through contact with contaminated blood — most commonly through needles shared during illegal drug use.
Hepatitis C infection usually produces no signs or symptoms during its earliest stages. When signs and symptoms do occur, they may include:
- Nausea or poor appetite
- Muscle and joint pains
- Yellowing of the skin and whites of the eyes (jaundice)
When to see a doctor
Make an appointment with your doctor if you have any signs and symptoms that worry you.
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Hepatitis C infection is caused by the hepatitis C virus (HCV). HCV is spread when you come in contact with blood contaminated with the virus.
Your risk of hepatitis C infection is increased if you:
- Are a health care worker who has been exposed to infected blood, such as may happen if an infected needle pierces your skin
- Have ever injected illicit drugs
- Have HIV
- Received a piercing or tattoo in an unclean environment using unsterile equipment
- Received a blood transfusion or organ transplant before 1992
- Received clotting factor concentrates before 1987
- Received hemodialysis treatments for a long period of time
- Were born to a woman with a hepatitis C infection
Hepatitis C infection that continues over many years can cause significant complications, such as:
- Scarring of the liver tissue (cirrhosis). After 20 to 30 years of hepatitis C infection, cirrhosis may occur. Scarring in your liver makes it difficult for your liver to function.
- Liver cancer. A small number of people with hepatitis C infection may develop liver cancer.
- Liver failure. A liver that is severely damaged by hepatitis C may be unable to function adequately.
Preparing for your appointment
Who to see
If you think you may have a risk of hepatitis C, see your family doctor or a general practitioner. Once you've been diagnosed with hepatitis C infection, your doctor may recommend you see a specialist. Specialists who see people with hepatitis C infection include:
- Doctors who specialize in infectious diseases
- Doctors who specialize in liver diseases (hepatologists)
How to prepare
Because appointments can be brief and because there's often a lot of ground to cover, it's a good idea to be well prepared. To prepare, try to:
- Be aware of any pre-appointment restrictions. At the time you make the appointment, be sure to ask if there's anything you need to do in advance, such as restrict your diet.
- Write down any symptoms you're experiencing, including any that may seem unrelated to the reason for which you scheduled the appointment.
- Write down key personal information, including any major stresses or recent life changes.
- Make a list of all medications, vitamins or supplements you're taking.
- Consider taking a family member or friend along. Sometimes it can be difficult to remember all the information provided during an appointment. Someone who accompanies you may remember something that you missed or forgot.
Questions to ask
Time with your doctor may be limited, so preparing a list of questions will help you make the most of your time together. List your questions from most important to least important, in case time runs out. For hepatitis C infection, some basic questions to ask your doctor include:
- How much hepatitis C virus do I have in my body?
- Should I be tested for other causes of liver disease, such as hepatitis B?
- Has the hepatitis C virus damaged my liver?
- Do I need treatment for hepatitis C infection?
- What are my treatment options?
- What are the benefits of each treatment option?
- What are the potential risks of each treatment option?
- Is there one treatment you think is best for me?
- I have other medical conditions. How will these affect my hepatitis C treatment?
- Should my family be tested for hepatitis C?
- Is it possible for me to spread hepatitis C to others?
- How can I protect the people around me from hepatitis C?
- Should I see a specialist? What will that cost, and will my insurance cover it?
- Are there brochures or other material that I can take with me? What websites do you recommend?
- What will determine whether I should plan for a follow-up visit?
- Is it safe for me to drink alcohol?
- What medications should I avoid?
In addition to the questions that you've prepared to ask your doctor, don't hesitate to ask questions that occur to you during your appointment.
What to expect from your doctor
Your doctor is likely to ask you a number of questions. Being ready to answer them may allow more time later to cover points you want to address. Your doctor may ask:
- When did you first begin experiencing symptoms?
- Have your symptoms been continuous or occasional?
- How severe are your symptoms?
- What, if anything, seems to improve your symptoms?
- What, if anything, appears to worsen your symptoms?
- Have you ever had a blood transfusion or an organ transplant? If so, when?
- Have you ever used self-injected drugs not prescribed by your doctor?
- Have you ever been diagnosed with hepatitis or jaundice?
- Does anyone in your family have hepatitis C?
- Is there a history of liver disease in your family?
Tests and diagnosis
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Screening for hepatitis C
Testing for hepatitis C infection in people who have a high risk of coming in contact with the virus may help doctors begin treatment or recommend lifestyle changes that may slow liver damage. This is recommended because hepatitis C infection often begins damaging the liver before it causes signs and symptoms.
People who may want to talk to their doctors about screening for hepatitis C infection include:
- Anyone who has ever injected illicit drugs
- Anyone with unexplained, unusual liver function test results
- Babies born to mothers with hepatitis C
- Health care and emergency workers who have been exposed to blood or accidental needle sticks
- People with hemophilia who were treated with clotting factors before 1987
- People who have ever undergone long-term hemodialysis treatments
- People who received blood transfusions or organ transplants before 1992
- Sexual partners of anyone diagnosed with hepatitis C infection
- People with HIV infection
- Anyone born from 1945 to 1965
Blood tests to diagnose hepatitis C
Blood tests may help to:
- Determine whether you have the hepatitis C virus
- Measure the quantity of the hepatitis C virus in your blood (viral load)
- Evaluate the genetic makeup of the virus (genotyping), which helps determine your treatment options
Testing samples of liver tissue to determine severity of liver damage
Your doctor may also recommend a procedure to remove a small sample of liver tissue for laboratory testing. A liver biopsy can help determine the severity of the disease and guide treatment decisions. During a liver biopsy, your doctor inserts a thin needle through your skin and into your liver to remove the tissue sample.
Treatments and drugs
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|Living liver transplant|
Treatment isn't always necessary
A diagnosis of hepatitis C infection doesn't necessarily mean you need treatment. If your doctor recommends no treatment, you'll undergo follow-up blood tests to monitor for liver problems.
Hepatitis C infection is treated with antiviral medications intended to clear the virus from your body. Your doctor may recommend a combination of medications taken over several weeks.
Throughout treatment your doctor will monitor your response to medications.
Antiviral medications can cause depression and flu-like signs and symptoms, such as fatigue, fever and headache. Some side effects can be serious enough that treatment must be delayed or stopped in certain cases.
If your liver has been severely damaged, a liver transplant may be an option. During a liver transplant, the surgeon removes your damaged liver and replaces it with a healthy liver. Most transplanted livers come from deceased donors, though a small number come from living donors who donate a portion of their livers.
For people with hepatitis C infection, a liver transplant is not a cure. Treatment with antiviral medications usually continues after a liver transplant, since hepatitis C infection is likely to recur in the new liver.
Vaccinations to protect against other forms of viral hepatitis
Your doctor will likely recommend that you receive vaccines against the hepatitis A and B viruses. These are separate viruses that also can cause liver damage and complicate treatment of hepatitis C.
Lifestyle and home remedies
If you receive a diagnosis of hepatitis C, your doctor will likely recommend certain lifestyle changes. These measures will help keep you healthy longer and protect the health of others as well:
- Stop drinking alcohol. Alcohol speeds the progression of liver disease.
- Avoid medications that may cause liver damage. Review your medications with your doctor, including the over-the-counter medications you take. Your doctor may recommend avoiding certain medications.
- Help prevent others from coming in contact with your blood. Cover any wounds you have and don't share razors or toothbrushes. Don't donate blood, body organs or semen, and advise health care workers that you have the virus.
No complementary or alternative medicine treatments have proved helpful in preventing or treating hepatitis C infection.
One herb that continues to attract attention for its touted liver-health properties is milk thistle. Proponents of milk thistle recommend the herb to treat jaundice and other liver disorders. People take milk thistle as a capsule, extract or infusion.
A clinical trial by the National Center for Complementary and Alternative Medicine found milk thistle was no better than a placebo at lowering liver enzyme levels in people with hepatitis C.
If you're interested in trying milk thistle, discuss the benefits and risks with your doctor.
Protect yourself from hepatitis C infection by taking the following precautions:
- Stop using illicit drugs. If you use illicit drugs, seek help.
- Be cautious about body piercing and tattooing. If you choose to undergo piercing or tattooing, look for a reputable shop. Ask questions beforehand about how the equipment is cleaned. Make sure the employees use sterile needles. If employees won't answer your questions, look for another shop.
- Practice safer sex if you choose to have sex. Don't engage in unprotected sex with multiple partners or with any partner whose health status is uncertain. Sexual transmission between monogamous couples may occur, but the risk is low.
- Mandell GL, et al. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 7th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2010. http://www.mdconsult.com/books/about.do?about=true&eid=4-u1.0-B978-0-443-06839-3..X0001-X--TOP&isbn=978-0-443-06839-3&uniqId=230100505-57. Accessed June 14, 2013.
- Feldman M, et al. Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 9th ed. Philadelphia, Pa.: Saunders Elsevier; 2010. http://www.mdconsult.com/books/about.do?eid=4-u1.0-B978-1-4160-6189-2..X0001-7--TOP&isbn=978-1-4160-6189-2&about=true&uniqId=229935664-2192. Accessed June 14, 2013.
- Diagnosis, management and treatment of hepatitis C: An update. Alexandria, Va.: American Association for the Study of Liver Disease. http://www.aasld.org/practiceguidelines/Pages/guidelinelisting.aspx. Accessed June 13, 2013.
- Hepatitis C FAQs for the public. Centers for Disease Control and Prevention. http://www.cdc.gov/hepatitis/C/cFAQ.htm. Accessed June 13, 2013.
- CAM and hepatitis C: A focus on herbal supplements. National Center for Complementary and Alternative Medicine. http://nccam.nih.gov/health/hepatitisc/hepatitiscfacts.htm. Accessed June 13, 2013.
- An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases. Alexandria, Va.: American Association for the Study of Liver Disease. http://www.aasld.org/practiceguidelines/Pages/guidelinelisting.aspx. Accessed June 13, 2013
- Centers for Disease Control and Prevention, et al. Recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945-1965. MMWR. 2012;61:1. http://www.cdc.gov/mmwr/preview/mmwrhtml/rr6104a1.htm?s_cid=rr6104a1_w. Accessed June 17, 2013.
- Picco MF (expert opinion). Mayo Clinic, Jacksonville, Fla. June 30, 2013.