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Causes
By Mayo Clinic staffCholesterol is carried through your blood, attached to proteins. This combination of proteins and cholesterol is called a lipoprotein. You may have heard of different types of cholesterol, based on what type of cholesterol the lipoprotein carries. They are:
- Low-density lipoprotein (LDL). LDL, or "bad," cholesterol transports cholesterol particles throughout your body. LDL cholesterol builds up in the walls of your arteries, making them hard and narrow.
- Very-low-density lipoprotein (VLDL). This type of lipoprotein contains the most triglycerides, a type of fat, attached to the proteins in your blood. VLDL cholesterol makes LDL cholesterol larger in size, causing your blood vessels to narrow. If you're taking cholesterol-lowering medication but have a high VLDL level, you may need additional medication to lower your triglycerides.
- High-density lipoprotein (HDL). HDL, or "good," cholesterol picks up excess cholesterol and takes it back to your liver.
Factors within your control — such as inactivity, obesity and an unhealthy diet — contribute to high LDL cholesterol and low HDL cholesterol. Factors beyond your control may play a role, too. For example, your genetic makeup may keep cells from removing LDL cholesterol from your blood efficiently or cause your liver to produce too much cholesterol.
- Cholesterol. American Heart Association. http://www.americanheart.org/presenter.jhtml?identifier=4488. Accessed April 20, 2010.
- High blood cholesterol: What you need to know. National Cholesterol Education Program. http://www.nhlbi.nih.gov/health/public/heart/chol/wyntk.pdf. Accessed April 20, 2010.
- Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/guidelines/cholesterol/atp3xsum.pdf. Accessed April 19, 2010.
- Arsenault BJ, et al. Beyond low-density lipoprotein cholesterol: Respective contributions of non-high-density lipoprotein cholesterol levels, triglycerides, and the total cholesterol/high-density lipoprotein cholesterol ratio to coronary heart disease risk in apparently healthy men and women. Journal of the American College of Cardiology. 2009;55:35.
- Daniels SR, et al. Lipid screening and cardiovascular health in childhood. Pediatrics. 2008;122:198.
- Ford ES, et al. Concentrations of low density lipoprotein cholesterol and total cholesterol among children and adolescents in the United States. Circulation. 2009;119:1108.
- Cholesterol lowering drugs. American Heart Association. http://www.americanheart.org/presenter.jhtml?identifier=163. Accessed April 19, 2010.
- Guyton JR, et al. Safety considerations with niacin therapy. Journal of the American College of Cardiology. 2007;99:22C.
- Koski RR. Omega-3-acid ethyl esters (Lovaza) for severe hypertriglyceridemia. Pharmacy and Therapeutics. 2008;33:271.
- Cooking for lower cholesterol. American Heart Association. http://www.americanheart.org/presenter.jhtml?identifier=515. Accessed April 26, 2010.
- Kodama S, et al. Effect of aerobic exercise training on serum levels of high-density lipoprotein cholesterol. Archives of Internal Medicine. 2007;167:999.
- Poli A, et al. Non-pharmacological control of plasma cholesterol levels. Nutrition and Metabolism in Cardiovascular Diseases. 2008;18:1.
- Natural medicines in clinical management of hyperlipidemia. Natural Medicines Comprehensive Database. http://www.naturaldatabase.com. Accessed April 23, 2010.
- FDA warns consumers to avoid red yeast rice products promoted on internet as treatments for high cholesterol products found to contain unauthorized drug. Food and Drug Administration. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2007/ucm108962.htm. Accessed April 26, 2010.
- Miller M, et al. Triglycerides and cardiovascular disease: A scientific statement from the American Heart Association. Circulation. In press. Accessed April 27, 2011.
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