High blood pressure (hypertension)

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Central-acting agents

Central-acting agents, also called central adrenergic inhibitors, treat several conditions, including high blood pressure, drug and alcohol withdrawal, and hot flashes. Find out more about these medications.

By Mayo Clinic staff

Central-acting agents lower your heart rate and reduce your blood pressure. They work by preventing your brain from sending signals to your nervous system to speed up your heart rate and narrow your blood vessels. As a result, your heart doesn't pump as hard and your blood flows more easily through your blood vessels.

Examples of central-acting agents

Central-acting agents are also called central adrenergic inhibitors, central alpha agonists and central agonists. Several central-acting agents are available. Which one is best for you depends on your health and the condition being treated.

Examples of central-acting agents include:

  • Clonidine (Catapres)
  • Guanfacine (Tenex)
  • Methyldopa
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References
  1. Clonidine: Martindale — The Complete Drug Reference. Micromedex Healthcare Series. http://www.micromedex.com/. Accessed Nov. 18, 2008.
  2. Sheps SG, ed. Mayo Clinic 5 Steps to Controlling High Blood Pressure. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2008:195.
  3. Initial antihypertensive therapy: Drugdex Consults. Micromedex Healthcare Series. http://www.micromedex.com/. Accessed Nov. 12, 2008.
  4. Blood pressure-lowering drugs. American Heart Association. http://www.americanheart.org/presenter.jhtml?identifier=159. Accessed Nov. 12, 2008.

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Dec. 18, 2008

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