High white blood cell count
What causes a high white blood cell count?
- No name / No state given
Mayo Clinic hematologist Ruben Mesa, M.D., and colleagues answer select questions from readers.
Answer
White blood cells (leukocytes) help fight infection in your body. A normal white blood cell count is between 4,500 and 10,000 cells per microliter. A high white blood cell count (leukocytosis) isn't a specific disease. But it may indicate an underlying problem that requires medical evaluation. Causes of a high white blood cell count include:
- Infection
- Use of certain medications, such as corticosteroids, antibiotics or anti-seizure drugs
- Severe physical or emotional stress
- Chronic bone marrow diseases such as a myeloproliferative disorder
- Acute or chronic leukemia
- Tissue damage, such as from burns


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