Risk factorsBy Mayo Clinic staff
The chances of developing histoplasmosis symptoms increase with the number of spores you inhale. Professions with a higher likelihood of spore exposure include:
- Pest control workers
- Poultry keepers
- Construction workers
- Landscapers and gardeners
Most at risk of severe infection
Very young children and older adults have weaker immune systems, so they're more likely to develop disseminated histoplasmosis — the most serious form of the disease. Other factors that can weaken your immune system include:
- HIV or AIDS
- Cancer chemotherapy
- Corticosteroid drugs, such as prednisone
- TNF inhibitors, often used to control rheumatoid arthritis
- Medications that prevent rejection of organ transplants
- Histoplasmosis. Centers for Disease Control and Prevention. http://www.cdc.gov/nczved/divisions/dfbmd/diseases/histoplasmosis. Accessed Dec. 20, 2011.
- Kaufman CA. Histoplasmosis. In: Goldman L, et al. Cecil Medicine. 24th ed. Philadelphia, Pa.: Saunders Elsevier; 2011. http://www.mdconsult.com/das/book/body/191371208-2/0/1492/0.html#. Accessed Dec. 20, 2011.
- Wheat J, et al. Pathogenesis and clinical features of pulmonary histoplasmosis. http://www.uptodate.com/home/index.html. Accessed Dec. 20, 2011.
- Hage CH, et al. Histoplasmosis: Introduction. In: Longo DL, et al. Harrison's Online. 18th ed. New York, N.Y.: The McGraw-Hill Companies; 2012. http://www.accessmedicine.com/resourceTOC.aspx?resourceID=4. Accessed Dec. 20, 2011.
- Fort GG, et al. Histoplasmosis. In: Ferri FF. Ferri's Clinical Advisor 2012: 5 Books in 1. Philadelphia, Pa.: Mosby Elsevier; 2012. http://www.mdconsult.com/books/about.do?about=true&eid=4-u1.0-B978-0-323-05611-3..C2009-0-38601-8--TOP&isbn=978-0-323-05611-3&uniqId=291436269-101. Accessed Dec. 20, 2011.
- Davies SF, et al. Fungal infections: Histoplasmosis. In: Mason RJ, et al. Murray and Nadel's Textbook of Respiratory Medicine. 5th ed. Philadelphia, Pa.: Saunders Elsevier; 2010. http://www.mdconsult.com/das/book/body/192068760-2/0/1288/0.html. Accessed Dec. 20, 2011.
- Histoplasmosis: Protecting workers at risk. Centers for Disease Control and Prevention. http://www.cdc.gov/niosh/docs/2005-109. Accessed Dec. 20, 2011.
- What is ARDS? National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/health-topics/topics/ards. Accessed Dec. 20, 2011.
- Van Duin D. Histoplasmosis. In: Bope ET, et al. Conn's Current Therapy. Philadelphia, Pa.: Saunders Elsevier; 2011. http://www.mdconsult.com/books/about.do?eid=4-u1.0-B978-1-4377-0986-5..C2009-0-38984-9--TOP&isbn=978-1-4377-0986-5&about=true&uniqId=236797353-5. Accessed Dec. 20, 2011.