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Causes
By Mayo Clinic staffScientists believe a virus similar to HIV first occurred in some populations of chimps and monkeys in Africa, where they're hunted for food. Contact with an infected monkey's blood during butchering or cooking may have allowed the virus to cross into humans and become HIV.
How does HIV become AIDS?
HIV destroys CD4 cells — a specific type of white blood cell that plays a large role in helping your body fight disease. Your immune system weakens as more CD4 cells are killed. You can have an HIV infection for years before it progresses to AIDS.
To be diagnosed with AIDS, you must have a CD4 count under 200 or experience an AIDS-defining complication, such as:
- Pneumocystis jiroveci pneumonia
- Cytomegalovirus
- Tuberculosis
- Toxoplasmosis
- Cryptosporidiosis
How HIV is transmitted
To become infected with HIV, infected blood, semen or vaginal secretions must enter your body. You can't become infected through ordinary contact — hugging, kissing, dancing or shaking hands — with someone who has HIV or AIDS. HIV can't be transmitted through the air, water or via insect bites.
You can become infected with HIV in several ways, including:
- During sex. You may become infected if you have vaginal, anal or oral sex with an infected partner whose blood, semen or vaginal secretions enter your body. The virus can enter your body through mouth sores or small tears that sometimes develop in the rectum or vagina during sexual activity.
- Blood transfusions. In some cases, the virus may be transmitted through blood transfusions. American hospitals and blood banks now screen the blood supply for HIV antibodies, so this risk is very small.
- Sharing needles. HIV can be transmitted through needles and syringes contaminated with infected blood. Sharing intravenous drug paraphernalia puts you at high risk of HIV and other infectious diseases such as hepatitis.
- From mother to child. Infected mothers can infect their babies during pregnancy or delivery, or through breast-feeding. But if women receive treatment for HIV infection during pregnancy, the risk to their babies is significantly reduced.
- Basic information about HIV and AIDS. Centers for Disease Control and Prevention. http://www.cdc.gov/hiv/topics/basic/index.htm. Accessed May 18, 2010.
- HIV and its treatment: What you should know. AIDSinfo. U.S. Department of Health and Human Services. http://aidsinfo.nih.gov/contentfiles/HIVandItsTreatment_cbrochure_en.pdf. Accessed May 18, 2010.
- Kumar V, et al. Immunodeficiency syndromes. In: Kumar V, et al. Robbins and Cotran Pathologic Basis of Disease, Professional Edition. 8th ed. Philadelphia, Pa.: Saunders Elsevier; 2009. http://www.mdconsult.com/das/book/body/202273019-4/0/2060/57.html?tocnode=57529567&fromURL=57.html#4-u1.0-B978-1-4377-0792-2..50011-0--cesec96_437. Accessed May 18, 2010.
- Quinn TC. The global human immunodeficiency virus pandemic. http://www.uptodate.com/home/index.html. Accessed May 18, 2010.
- Opal SM, et al. Human immunodeficiency virus. In: Ferri FF. Ferri's Clinical Advisor 2010. Philadelphia, Pa.: Mosby Elsevier; 2009. http://www.mdconsult.com/das/book/body/202273019-4/1002085996/2088/313.html#4-u1.0-B978-0-323-05609-0..00017-4--sc0185_6437. Accessed May 18, 2010.
- Bartlett JG. The stages and natural history of HIV infection. http://www.uptodate.com/home/index.html. Accessed May 18, 2010.
- Opal SM, et al. Acquired immunodeficiency syndrome. In: Ferri FF. Ferri's Clinical Advisor 2010. Philadelphia, Pa.: Mosby Elsevier; 2009. http://www.mdconsult.com/das/book/body/202273019-4/1002085996/2088/22.html#4-u1.0-B978-0-323-05609-0..00010-1--s1620_340. Accessed May 18, 2010.
- Living with AIDS. Centers for Disease Control and Prevention. http://www.cdc.gov/hiv/resources/brochures/livingwithhiv.htm. Accessed May 19, 2010.
- Neurological complications of AIDS fact sheet. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/aids/detail_aids.htm. Accessed May 21, 2010.
- Bartlett JG. When to initiate antiretroviral therapy in HIV-infected patients. http://www.uptodate.com/home/index.html. Accessed May 21, 2010.
- Side effects of anti-HIV medications: Health information for patients. AIDSinfo. U.S. Department of Health and Human Services. http://aidsinfo.nih.gov/contentfiles/SideEffectAnitHIVMeds_cbrochure_en.pdf. Accessed May 21, 2010.
- Eating defensively: Food safety advice for persons with AIDS. U.S. Food and Drug Administration. http://www.fda.gov/ForConsumers/ByAudience/ForPatientAdvocates/HIVandAIDSActivities/ucm135844.htm. Accessed May 21, 2010.
- Natural medicines in the clinical management of HIV/AIDS. Natural Medicines Comprehensive Database. http://www.naturaldatabase.com. Accessed May 21, 2010.
- The HIV/AIDS programs: Find HIV/AIDS care. U.S. Department of Health and Human Services. http://hab.hrsa.gov/findcare/index.htm. Accessed May 21, 2010.
- Fourth generation HIV diagnostic test approved, permitting earlier detection of infection. Food and Drug Administration. http://www.fda.gov/ForConsumers/ByAudience/ForPatientAdvocates/HIVandAIDSActivities/ucm216409.htm. Accessed June 24, 2010.
- FDA approves first-of-its-kind HIV test which can detect HIV days earlier than current U.S. tests. Abbott Laboratories. http://www.abbott.com/global/url/pressRelease/en_US/60.5:5/Press_Release_0875.htm. Accessed June 24, 2010.
- Daar ES, et al. Clinical presentation and diagnosis of primary HIV-1 infection. Current Opinion in HIV and AIDS. 2008;3:110.
- Sax, PE. Primary HIV-1 infection: Pathogenesis; epidemiology and clinical manifestations. http://www.uptodate.com/home/index.html. Accessed Oct. 17, 2011.
- Stages of HIV. U.S. Department of Health and Human Services. http://www.aids.gov/hiv-aids-basics/diagnosed-with-hiv-aids/hiv-in-your-body/stages-of-hiv/. Accessed Oct. 19, 2011.
- Fauci A, et al. Human immunodeficiency virus disease: AIDS and related disorders. In: Longo DL, et al. Harrison's Online. 18th ed. New York, N.Y.: The McGraw-Hill Companies; 2012. http://www.accessmedicine.com/resourceTOC.aspx?resourceID=4. Accessed Oct. 19, 2011.
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