How you prepareBy Mayo Clinic staff
There are several options for hormone therapy for prostate cancer. Before you undergo hormone therapy for prostate cancer, talk to your doctor to decide which approach is best for you:
- Medications that stop your body from producing testosterone. Medications known as luteinizing hormone-releasing hormone (LHRH) agonists and antagonists prevent cells in the body from receiving messages to make testosterone, causing the production of testosterone in the testicles to stop.
- Medications that block testosterone from reaching cancer cells. Medications known as anti-androgens prevent testosterone from reaching your cancer cells. These medications usually are given in conjunction with LHRH agonists because LHRH agonists can cause a temporary increase in testosterone before testosterone levels decrease.
- Surgery to remove the testicles (orchiectomy). Removing your testicles reduces testosterone levels in your body quickly and significantly. But unlike medication options, surgery to remove the testicles is permanent and irreversible.
Wein AJ, et al. Campbell-Walsh Urology. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.mdconsult.com/books/about.do?about=true&eid=4-u1.0-B978-1-4160-6911-9..C2009-1-60786-3--TOP&isbn=978-1-4160-6911-9&uniqId=310232887-6. Accessed March 20, 2013.
- Prostate cancer. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed March 21, 2013.
- Dawson NA. Secondary endocrine therapies for castration-resistant prostate cancer. http://www.uptodate.com/home. Accessed March 20, 2013.