Free
E-newsletter
Subscribe to Housecall
Our weekly general interest
e-newsletter keeps you up to date
on a wide variety of health topics.
Mayo Clinic Housecall
Stay up to date on the latest health information.
What you get
- Free weekly e-newsletter
- Mayo Clinic expertise
- Recipes, tools and other helpful information
- We do not share your e-mail address
Causes
By Mayo Clinic staffHorner syndrome is caused by damage to the sympathetic nerves of your face and eyes. Sympathetic nerves control your body's circulation and sweating. Depending on where the nerves are damaged, Horner syndrome is often classified in two groups.
Central
Sympathetic nerves in your face start in an area of your brain known as the hypothalamus, travel through the brainstem and then down your spinal cord to enter your chest. This is the first half of their "route." Possible causes of nerve damage in this area are:
- Stroke (usually a cerebral infarction or most commonly a brainstem location)
- Tumor
- Syringomyelia — a condition in which a fluid-filled cyst (syrinx) develops within your spinal cord
- Cluster headaches
Peripheral
From your chest, your sympathetic nerves go back up your neck, next to the main arteries that deliver blood to your head (carotid arteries), into your skull and then to your eyes. Nerve damage in this area may be caused by:
- Spinal cord injury
- A tear in the inner lining of one of your carotid arteries (carotid artery dissection)
- An injury to a baby during birth
- Lung cancer in the apex of the lung
Although Horner syndrome may be a sign of one of these conditions, in some situations, a specific cause can't be found. This is known as idiopathic Horner syndrome.
- Kedar S, et al. Horner's syndrome. http://www.uptodate.com/home/index.html. Accessed Jan. 20, 2011.
- Horner's syndrome. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merckmanuals.com/professional/sec16/ch208/ch208c.html. Accessed Jan. 20, 2011.
- Levsky ME, et al. Ophthalmologic conditions. In: Knoop KJ, et al. Atlas of Emergency Medicine. 3rd ed. New York, N.Y.: The McGraw-Hill Companies; 2010. http://www.accessmedicine.com/content.aspx?aID=6000511&searchStr=horner's+syndrome. Accessed Jan. 20, 2011.
- Ropper AH, et al. Disorders of ocular movement and pupillary function. In: Ropper AH, et al. Adams and Victor's Principles of Neurology. 9th ed. New York, N.Y.: The McGraw-Hill Companies; 2009. http://www.accessmedicine.com/content.aspx?aID=3631985&searchStr=horner's+syndrome#3631985. Accessed Jan. 20, 2011.
- Braverman RS. Eye. In: Hay WW, et al. Current Diagnosis & Treatment: Pediatrics. 20th ed. New York, N.Y.: The McGraw-Hill Companies; 2011. http://www.accessmedicine.com/content.aspx?aID=6580881&searchStr=horner's+syndrome. Accessed Jan. 20, 2011.
- Robertson DM (expert opinion). Mayo Clinic, Rochester, Minn. Jan. 27, 2011.
- Swanson JW (expert opinion). Mayo Clinic, Rochester, Minn. Jan. 26, 2011.
Find Mayo Clinic on