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Causes
By Mayo Clinic staffDuring digestion, your body breaks down carbohydrates from foods — such as bread, rice and pasta — into various sugar molecules. One of these sugar molecules is glucose, a main energy source for your body. Glucose is absorbed directly into your bloodstream after you eat, but it can't enter the cells of most of your tissues without the help of insulin — a hormone secreted by your pancreas.
When the level of glucose in your blood rises, it signals your pancreas to release insulin. The insulin, in turn, unlocks your cells so that glucose can enter and provide the fuel your cells need to function properly. Any extra glucose is stored in your liver and muscles in the form of glycogen. This process lowers the amount of glucose in your bloodstream and prevents it from reaching dangerously high levels. As your blood sugar level returns to normal, so does the secretion of insulin from your pancreas.
For people with diabetes, the effects of insulin on your body are drastically diminished, either because your pancreas doesn't produce enough insulin (type 1 diabetes) or because your body is resistant to the effects of insulin or doesn't produce enough insulin to maintain a normal glucose level (type 2 diabetes). As a result, glucose tends to build up in your bloodstream and may reach dangerously high levels (hyperglycemia) if not treated properly. Insulin or other drugs are used to lower blood sugar levels.
Factors that contribute to hyperglycemia
Many factors can contribute to hyperglycemia, including:
- Not using enough insulin or oral diabetes medication
- Not injecting insulin properly or using expired insulin
- Not following your diabetes eating plan
- Being inactive
- Having an illness or infection
- Using medications, such as steroids
- Being injured or having surgery
- Experiencing emotional stress, such as family conflict or workplace challenges
Illness or stress can trigger hyperglycemia because hormones produced to combat illness or stress can also cause your blood sugar to rise. Even people who don't have diabetes may develop hyperglycemia during severe illness. But people with diabetes may need to take extra diabetes medication to keep blood glucose near normal during illness or stress.
- Hyperglycemia (high blood glucose). American Diabetes Association. http://www.diabetes.org/living-with-diabetes/treatment-and-care/blood-glucose-control/hyperglycemia.html. Accessed Dec. 9, 2009.
- Nathan DM, et al. Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2009;32:193.
- Shane F, et al. Metabolic and endocrine emergencies. In: Stone CK, et al. Current Diagnosis and Treatment: Emergency Medicine. 6th ed. New York, N.Y.: The McGraw-Hill Companies; 2008. http://www.accessmedicine.com/content.aspx?aID=3112282. Accessed Dec. 22, 2009.
- Collazo-Clavell ML (expert opinion). Mayo Clinic, Rochester, Minn. Feb. 2, 2010.
- A1C. American Diabetes Association. http://www.diabetes.org/living-with-diabetes/treatment-and-care/blood-glucose-control/a1c/. Accessed Dec. 22, 2009.
- Kitabchi AE, et al. Clinical features and diagnosis of diabetic ketoacidosis and hyperosmolar hyperglycemic state in adults. http://www.uptodate.com/home/index.html. Accessed Dec. 22, 2009.
- Your guide to diabetes: Type 1 and type 2. Diabetes overview. National Institute of Diabetes and Digestive and Kidney Diseases. http://diabetes.niddk.nih.gov/DM/pubs/type1and2/YourGuide2Diabetes.pdf. Accessed Dec. 23, 2009.
- Checking your blood glucose. American Diabetes Association. http://www.diabetes.org/type-2-diabetes/blood-glucose-checks.jsp. Accessed March 5, 2010.
- American Diabetes Association. Standards of medical care in diabetes — 2010. Diabetes Care. 2010;33:S11
- Diagnosis and Management of Type 2 Diabetes Mellitus in Adults. Bloomington, Minn.: Institute for Clinical Systems Improvement. http://www.icsi.org/diabetes_mellitus__type_2/management_of_type_2_diabetes_mellitus__9.html. Accessed March 3, 2010.
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