Hyperthyroidism (overactive thyroid)

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Symptoms

By Mayo Clinic staff

Hyperthyroidism can mimic other health problems, which may make it difficult for your doctor to diagnose. It can also cause a wide variety of signs and symptoms, including:

  • Sudden weight loss, even when your appetite and the amount and type of food you eat remain the same or even increase
  • Rapid heartbeat (tachycardia) — commonly more than 100 beats a minute — irregular heartbeat (arrhythmia) or pounding of your heart (palpitations)
  • Increased appetite
  • Nervousness, anxiety and irritability
  • Tremor — usually a fine trembling in your hands and fingers
  • Sweating
  • Changes in menstrual patterns
  • Increased sensitivity to heat
  • Changes in bowel patterns, especially more frequent bowel movements
  • An enlarged thyroid gland (goiter), which may appear as a swelling at the base of your neck
  • Fatigue, muscle weakness
  • Difficulty sleeping
  • Skin thinning
  • Fine, brittle hair

Older adults are more likely to have either no signs or symptoms or subtle ones, such as an increased heart rate, heat intolerance and a tendency to become tired during ordinary activities. Medications called beta blockers, which are used to treat high blood pressure and other conditions, can mask many of the signs of hyperthyroidism.

Graves' ophthalmopathy
Sometimes an uncommon problem called Graves' ophthalmopathy may affect your eyes, especially if you smoke. In this disorder, your eyeballs protrude beyond their normal protective orbits when the tissues and muscles behind your eyes swell. This pushes the eyeballs forward so far that they actually bulge out of their orbits. This can cause the front surface of your eyeballs to become very dry. Eye problems often improve without treatment.

Signs and symptoms of Graves' ophthalmopathy include:

  • Protruding eyeballs
  • Red or swollen eyes
  • Excessive tearing or discomfort in one or both eyes
  • Light sensitivity, blurry or double vision, inflammation, or reduced eye movement

When to see a doctor
If you experience unexplained weight loss, a rapid heartbeat, unusual sweating, swelling at the base of your neck or other symptoms associated with hyperthyroidism, see your doctor. It's important to completely describe the changes you've observed, because many signs and symptoms of hyperthyroidism may be associated with a number of other conditions.

If you've been treated for hyperthyroidism or currently are being treated, see your doctor regularly as advised so that he or she can monitor your condition.

References
  1. Hyperthyroidism. The American Thyroid Association. http://www.thyroid.org/what-is-hyperthyroidism. Accessed July 17, 2012.
  2. Soetters MR, et al. Optimal management of Graves orbitopathy: A multidisciplinary approach. The Netherlands Journal of Medicine. 2011;69:302.
  3. Brandt F, et al. A critical review and meta-analysis of the association between overt hyperthyroidism and mortality. European Journal of Endocrinology. 2011;165:491.
  4. Graves' disease. Womenshealth.gov. http://www.womenshealth.gov/faq/graves-disease.cfm. Accessed July 17, 2012.
  5. Hyperthyroidism. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merckmanuals.com/professional/sec12/ch152/ch152e.html. Accessed July 25, 2012.
  6. Graves' disease. National Endocrine and Metabolic Diseases Information Service. http://www.endocrine.niddk.nih.gov/pubs/graves/Graves.pdf. Accessed July 25, 2012.
  7. Hyperthyroidism. National Endocrine and Metabolic Diseases Information Service. http://www.endocrine.niddk.nih.gov/pubs/hyperthyroidism/index.aspx. Accessed July 25, 2012.
  8. Dietary Reference Intakes for calcium and vitamin D. Institute of Medicine. http://www.iom.edu/vitamind. Accessed July 17, 2012.
  9. Bahn RS, et al. Hyperthyroidism and other causes of thyrotoxicosis: Management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid. 2011;21:593.
  10. Thyroid problems. Hormone Health Network. http://www.hormone.org/thyroid_problems.cfm. Accessed July 26, 2012.
  11. Stan MN, et al. The evaluation and treatment of Graves ophthalmopathy. Medical Clinics of North America. 2012;96:311.
  12. Schwartz KM, et al. Dermopathy of Grave's disease (pretibial myxedema): Long-term outcome. The Journal of Clinical Endocrinology & Metabolism. 2002;77:438.
  13. Nippoldt TB (expert opinon). Mayo Clinic, Rochester, Minn. Aug. 14, 2012.
DS00344 Nov. 20, 2012

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