Treatments and drugsBy Mayo Clinic staff
Lifestyle changes may help ease indigestion. Your doctor may recommend:
- Avoiding foods that trigger indigestion
- Eating five or six small meals a day instead of three large meals
- Reducing or eliminating the use of alcohol and caffeine
- Avoiding certain pain relievers, such as aspirin, ibuprofen and naproxen
- Finding alternatives for medications that trigger indigestion
- Controlling stress and anxiety
If your indigestion persists, medications may help. Over-the-counter antacids are generally the first choice. Other options include:
- Proton pump inhibitors (PPIs), which can reduce stomach acid. PPIs may be recommended if you experience heartburn along with indigestion.
- H-2-receptor antagonists (H2RAs), which also can reduce stomach acid.
- Prokinetics, which may be helpful if your stomach empties slowly.
- Antibiotics, if H. pylori bacteria are causing your indigestion.
- Antidepressants or anti-anxiety medications, which may ease the discomfort from indigestion by decreasing your sensation of pain.
- Feldman M, et al. Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 9th ed. Philadelphia, Pa.: Saunders Elsevier; 2010. http://www.mdconsult.com/books/about.do?eid=4-u1.0-B978-1-4160-6189-2..X0001-7--TOP&isbn=978-1-4160-6189-2&about=true&uniqId=229935664-2192. Accessed Feb. 25, 2013.
- AskMayoExpert. What is the recommended work-up for a patient with dyspepsia? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2012.
- Indigestion. National Digestive Diseases Information Clearinghouse. http://digestive.niddk.nih.gov/ddiseases/pubs/indigestion/index.aspx. Accessed Feb. 25, 2013.
- Papadakis MA, et al. Current Medical Diagnosis & Treatment 2013. 52nd ed. New York, N.Y.: The McGraw-Hill Companies; 2013. http://www.accessmedicine.com/resourcetoc.aspx?resourceid=1. Accessed Feb. 25, 2013.
- Dyspepsia. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merckmanuals.com/professional/print/gastrointestinal_disorders/approach_to_the_patient_with_upper_gi_complaints/dyspepsia.html. Accessed Feb. 26, 2013.
- Lacy BE, et al. Review article: Current treatment options and management of functional dyspepsia. Alimentary Pharmacology & Therapeutics. 2012;36:3.
- Camilleri M, et al. Current management strategies and emerging treatments for functional dyspepsia. Nature Reviews Gastroenterology & Hepatology. In press. Accessed Feb. 26, 2013.
- Zeng F, et al. Influence of acupuncture treatment on cerebral activity in functional dyspepsia patients and its relationship with efficacy. American Journal of Gastroenterology. 2012;107:1236.