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Complications

By Mayo Clinic staff

Severe jaundice, if left untreated, can cause serious complications.

Acute bilirubin encephalopathy
Bilirubin is toxic to cells of the brain. If a baby has severe jaundice, there's a risk of bilirubin passing into the brain, a condition called acute bilirubin encephalopathy. Prompt treatment may prevent significant permanent damage.

The following signs may indicate acute bilirubin encephalopathy in a baby with jaundice:

  • Listless, sick or difficult to wake
  • High-pitched crying
  • Poor sucking or feeding
  • Backward arching of the neck and body
  • Fever
  • Vomiting

Kernicterus
Kernicterus is the syndrome that occurs if acute bilirubin encephalopathy causes permanent damage to the brain. Kernicterus may result in:

  • Involuntary and uncontrolled movements (athetoid cerebral palsy)
  • Permanent upward gaze
  • Hearing loss
  • Intellectual impairment
References
  1. Jaundice. American Academy of Pediatrics. http://www.healthychildren.org/English/ages-stages/baby/Pages/Jaundice.aspx. Accessed Feb. 24, 2011.
  2. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. American Academy of Pediatrics Policy. http://aappolicy.aappublications.org/cgi/content/full/pediatrics;114/1/297. Accessed Feb. 24, 2011.
  3. Neonatal hyperbilirubinemia. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merckmanuals.com/professional/sec19/ch274/ch274b.html?qt=neonatal%20hyperbilirubinemia&alt=sh. Accessed Feb. 24, 2011.
  4. Lease M, et al. Assessing jaundice in infants of 35-week gestation and greater. Current Opinion in Pediatrics. 2010;22:352.
  5. Cohen RS, et al. Understanding neonatal jaundice: A perspective on causation. Pediatric Neonatology. 2010;51:143.
  6. Wong RJ, et al. Treatment of unconjugated hyperbilirubinemia in term and late preterm infants. http://www.uptodate.com/home/index.html. Accessed Feb. 24, 2011.
  7. Moerschel SK, et al. A practical approach to neonatal jaundice. American Family Physician. 2008;77:1255.
DS00107 April 14, 2011

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