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Causes
By Mayo Clinic staff
Your bladder is a hollow, muscular, balloon-shaped organ that stores urine until you're ready to empty it. In adults, the bladder expands until it's full and then signals the brain that it's time to urinate, by communicating through the pelvic nerves. This creates the urge to urinate in most people. With interstitial cystitis, these signals somehow get mixed up, and you feel the need to urinate more often and with smaller volumes of urine than most people.
It's likely that many people with interstitial cystitis also have a defect in the protective lining (epithelium) of their bladder. A leak in the epithelium, for example, may allow toxic substances in urine to irritate your bladder wall.
Suggested but unproven factors that may contribute to interstitial cystitis include an autoimmune reaction, heredity, infection or allergy.
- Interstitial cystitis/painful bladder syndrome. National Institute of Diabetes and Digestive and Kidney Diseases. http://kidney.niddk.nih.gov/kudiseases/pubs/interstitialcystitis/. Accessed Nov. 23, 2010.
- Fitzgerald MP. Clinical features and diagnosis of painful bladder syndrome/interstitial cystitis. http://www.uptodate.com/home/index.html. Accessed Nov. 23, 2010.
- Interstitial cystitis. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merckmanuals.com/professional/print/sec17/ch228/ch228e.html. Accessed Nov. 23, 2010.
- Hanno PM, et al. Bladder pain syndrome. Medical Clinics of North America. 2011;95:55.
- Hanno PM. Painful bladder syndrome/interstitial cystitis and related disorders. In: Wein AJ, et al. Campbell-Walsh Urology. 9th ed. Philadelphia, Pa.: Saunders Elsevier; 2007. http://www.mdconsult.com/das/book/body/113536197-2/0/1445/13.html?tocnode=54300277&fromURL=13.html#4-u1.0-B978-0-7216-0798-6..50012-1_840. Accessed Nov. 23, 2010.
- Engelhardt PF, et al. Long-term results of intravesical hyaluronan therapy in bladder pain syndrome/interstitial cystitis. International Urogynecology Journal. In Press. Accessed Nov. 23, 2010.
- Homma Y, et al. Clinical guidelines for interstitial cystitis and hypersensitive bladder syndrome. International Journal of Urology. 2009;16:597.
- Fitzgerald MP. Treatment of painful bladder syndrome/interstitial cystitis. http://www.uptodate.com/home/index.html. Accessed Nov. 23, 2010.
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