Interstitial lung disease

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Risk factors

By Mayo Clinic staff

Factors that may make you more susceptible to interstitial lung disease include:

  • Age. Interstitial lung disease is much more likely to affect adults, although infants and children sometimes develop the disorder.
  • Exposure to occupational and environmental toxins. If you work in mining, farming or construction or for any reason are exposed to pollutants known to damage your lungs, your risk of interstitial lung disease greatly increases.
  • Smoking. Some forms of interstitial lung disease are more likely to occur in people with a history of smoking, and active smoking may make the condition worse.
  • Radiation and chemotherapy. Having radiation treatments to your chest or using some chemotherapy drugs makes it more likely that you'll develop lung disease.
  • Oxygen. Continually inhaling very high levels of therapeutic oxygen for more than 48 hours can harm the lungs.
References
  1. Olson AL, et al. Interstitial lung disease. In: Schraufnagel DE, et al. Breathing in America: Diseases, Progress and Hope. New York, N.Y.: American Thoracic Society; 2010. http://www.thoracic.org/education/breathing-in-america.pdf. Accessed May 20, 2011.
  2. Selman M, et al. Clinical, radiologic and physiologic features of interstitial lung diseases. In: Mason RJ, et al. Murray and Nadel's Textbook of Respiratory Medicine. 5th ed. Philadelphia, Pa.: Saunders Elsevier; 2010. http://www.mdconsult.com/das/book/body/192068760-2/0/1288/0.html. Accessed May 23, 2011.
  3. King TE. Approach to the adult with interstitial lung disease: Clinical evaluation. http://www.uptodate.com/home/index.html. Accessed May 20, 2011.
  4. Raghu G. Interstitial lung disease. In: Goldman L, et al. Cecil Medicine. 23rd ed. Philadelphia, Pa.: Saunders Elsevier; 2008. http://www.mdconsult.com/das/book/body/191371208-2/0/1492/0.html#. Accessed May 20, 2011.
  5. What is idiopathic pulmonary fibrosis? National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/dci/Diseases/ipf/ipf_all.html. Accessed May 25, 2011.
  6. Shih G, et al. Interstitial lung disease. In: Ferri FF. Ferri's Clinical Advisor 2011: Instant Diagnosis and Treatment. Philadelphia, Pa.: Mosby Elsevier; 2011. http://www.mdconsult.com/books/about.do?eid=4-u1.0-B978-0-323-05610-6..C2009-0-38600-6--TOP&isbn=978-0-323-05610-6&about=true&uniqId=230100505-53. Accessed May 25, 2011.
  7. King TE. Treatment of idiopathy pulmonary fibrosis. http://www.uptodate.com/home/index.html. Accessed May 25, 2011.
  8. Pulmonary rehabilitation. National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/dci/Diseases/pulreh/pulreh_all.html. Accessed May 25, 2011.
DS00592 July 9, 2011

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