RisksBy Mayo Clinic staff
Intrauterine insemination is a relatively simple and safe procedure, and the risk of serious complications is low. Risks include:
- Infection. Studies indicate that fewer than 1 percent of women experience infection as a result of the procedure.
- Spotting. Sometimes the process of placing the catheter in the uterus can cause a small amount of vaginal bleeding. This does not usually have an effect on the chance of pregnancy.
- Multiple pregnancy. IUI itself is not associated with an increased risk of a multiple pregnancy — twins, triplets or more. However, when coordinated with ovulation-inducing medications, the risk of a multiple pregnancy increases significantly. A multiple pregnancy has higher risks than a single pregnancy does, including early labor and low birth weight.
- Frequently asked questions. Treating infertility. Gynecological problems FAQ137. American College of Obstetricians and Gynecologists. http://www.acog.org/~/media/For%20Patients/faq137.pdf?dmc=1&ts=20130521T2008087677. Accessed May 21, 2013.
- Reproductive health: Infertility FAQs. Centers for Disease Control and Prevention. http://www.cdc.gov/reproductivehealth/Infertility/. Accessed May 21, 2013.
- Infertility fact sheet. Womenshealth.gov. http://www.womenshealth.gov/publications/our-publications/fact-sheet/infertility.html. Accessed May 21, 2013.
- Ginsberg ES. Procedure for intrauterine insemination (IUI) using processed sperm. http://www.uptodate.com/home. Accessed May 21, 2013.
- Tournaye HJ, et al. Management of male-factor infertility. Best Practice and Research: Clinical Obstetrics and Gynaecology. 2012;26:769.
- Demir B, et al. Factors affecting pregnancy outcome of intrauterine insemination cycles in couples with favorable female characteristics. Journal of Obstetrics and Gynaecology. 2011;31:420.
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- Coddington III CC (expert opinion). Mayo Clinic, Rochester, Minn. May 23, 2013.
- Stewart EA (expert opinion). Mayo Clinic, Rochester, Minn. June 17, 2013.