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Definition

By Mayo Clinic staff

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Illustration showing parts of the breast
Breast anatomy

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Invasive lobular carcinoma is a type of breast cancer that begins in the milk-producing glands (lobules) of the breast. Invasive lobular carcinoma is invasive cancer. That means the cancer cells have broken out of the lobule where they began and have the potential to spread to other areas of the body.

Invasive lobular carcinoma makes up a small portion of all breast cancers. The most common type of breast cancer begins in the breast ducts (ductal carcinoma).

Invasive lobular carcinoma typically doesn't form a lump, as most women expect with breast cancer. Instead, invasive lobular carcinoma more often causes a thickening of the tissue or fullness in one part of the breast.

References
  1. Rakha EA, et al. Lobular breast carcinoma and its variants. Seminars in Diagnostic Pathology. 2010;27:49.
  2. Chen WY. Postmenopausal hormone therapy and breast cancer risk: Current status and unanswered questions. Endocrinology and Metabolism Clinics of North America. 2011;40:509.
  3. Abeloff MD, et al. Abeloff's Clinical Oncology. 4th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2008. http://www.mdconsult.com/das/book/body/208746819-4/0/1709/0.html. Accessed April 24, 2012.
  4. Breast cancer. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed April 24, 2012.
  5. Biglia N, et al. Increased incidence of lobular breast cancer in women treated with hormone replacement therapy: Implications for diagnosis, surgical and medical treatment. Endocrine-Related Cancer. 2007;14:549.
  6. Schrader KA, et al. Hereditary diffuse gastric cancer: Association with lobular breast cancer. Familial Cancer. 2008;7:73.
  7. Breast cancer treatment (PDQ). National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/treatment/breast/healthprofessional. Accessed April 24, 2012.
  8. Breast cancer prevention (PDQ). National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/prevention/breast/healthprofessional. Accessed April 24, 2012.
  9. Avis NE. Breast cancer survivors and hot flashes: The search for nonhormonal treatments. Journal of Clinical Oncology. 2008;26:5008.
  10. Pruthi S (expert opinion). Mayo Clinic, Rochester, Minn. May 7, 2012.
DS01063 May 22, 2012

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