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Definition

By Mayo Clinic staff

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Illustration of breast, including lymph nodes, lobules and ducts 
Breast anatomy

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Invasive lobular carcinoma is a type of breast cancer that begins in the milk-producing glands (lobules) of the breast. Invasive lobular carcinoma is invasive cancer, which means the cancer cells have broken out of the lobule where they began and they have the potential to spread to other areas of the body.

Invasive lobular carcinoma makes up a small portion of all breast cancers. The most common type of breast cancer begins in the breast ducts (ductal carcinoma). Some breast cancers contain both lobular and ductal cancer cells.

Invasive lobular carcinoma typically doesn't form a lump, as most women expect with breast cancer. Instead, invasive lobular carcinoma more often causes a thickening of the tissue or fullness in one part of the breast.

References
  1. Hanby AM, et al. In situ and invasive lobular neoplasia of the breast. Histopathology. 2008;52:58.
  2. Katz A, et al. Primary systemic chemotherapy of invasive lobular carcinoma of the breast. Lancet Oncology. 2007;8:55.
  3. Abeloff MD, et al. Cancer of the breast. In: Abeloff MD, et al. Abeloff's Clinical Oncology. 4th ed. Philadelphia, Pa.: Churchill Livingstone; 2008:1875.
  4. Breast cancer. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/PDF/breast.pdf. Accessed Jan. 20, 2010.
  5. Biglia N, et al. Increased incidence of lobular breast cancer in women treated with hormone replacement therapy: Implications for diagnosis, surgical and medical treatment. Endocrine-Related Cancer. 2007;14:549.
  6. Pestalozzi BC. Portrait of invasive lobular carcinoma of the breast. European Journal of Cancer. 2009;45(suppl):450.
  7. Eheman CR, et al. The changing incidence of in situ and invasive ductal and lobular breast carcinomas: United States, 1999-2004. Cancer Epidemiology, Biomarkers & Prevention. 2009;18:1763.
  8. Mann RM, et al. MRI compared to conventional diagnostic work-up in the detection and evaluation of invasive lobular carcinoma of the breast: A review of the existing literature. Breast Cancer Research and Treatment. 2008;107:1.
  9. Schrader KA, et al. Hereditary diffuse gastric cancer: Association with lobular breast cancer. Familial Cancer. 2008;7:73.
  10. Breast cancer treatment (PDQ): Health professional version. National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/treatment/breast/healthprofessional/allpages/print. Accessed Feb. 16, 2010.
  11. Breast cancer prevention (PDQ): Health professional version. National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/prevention/breast/healthprofessional/allpages/print. Accessed Feb. 16, 2010.
  12. Avis NE. Breast cancer survivors and hot flashes: The search for nonhormonal treatments. Journal of Clinical Oncology. 2008;26:5008.
  13. Polednak A. Bilateral synchronous breast cancer: A population-based study of characteristics, method of detection, and survival. Surgery. 2003;133:383.
  14. Goldflam K, et al. Contralateral prophylactic mastectomy: Predictors of significant histologic findings. Cancer. 2004;101:1977.
  15. Pruthi S (expert opinion). Mayo Clinic, Rochester, Minn. Dec. 9, 2010.
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