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Causes
By Mayo Clinic staff
It's not clear what causes renal cell carcinoma. Doctors know that kidney cancer begins when some kidney cells acquire mutations in their DNA. The mutations tell the cells to grow and divide rapidly. The accumulating abnormal cells form a tumor that can extend beyond the kidney. Some cells can break off and spread (metastasize) to distant parts of the body.
References
- Kidney cancer. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/PDF/kidney.pdf. Accessed Jan. 6, 2010.
- Pili R, et al. Cancer of the kidney. In: Abeloff MD, et al. Abeloff's Clinical Oncology. 4th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2008:1613.
- What you need to know about kidney cancer. National Cancer Institute. http://www.cancer.gov/cancertopics/wyntk/kidney/allpages/print. Accessed Jan. 7, 2010.
- Distress management. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/PDF/distress.pdf. Accessed Jan. 14, 2010.
- Campbell SC, et al. Malignant renal tumors. In: Wein AJ, et al. Campbell-Walsh Urology. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.mdconsult.com/das/book/body/208746819-6/0/1445/0.html. Accessed Jan. 9, 2012.
- Inlyta (prescribing information). New York, N.Y.: Pfizer Inc.; 2012. http://labeling.pfizer.com/ShowLabeling.aspx?id=759. Accessed Jan. 27, 2012.
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