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Causes
By Mayo Clinic staff
Your kidneys are the key organs in the complex filtration system that removes excess fluid and waste material from the blood. Your kidneys receive blood through your renal arteries, which branch off the main artery (the abdominal aorta) carrying oxygenated blood away from your heart. On entering the kidneys, blood is distributed through smaller and smaller vessels, finally reaching tiny capillary blood vessels arranged in tufts (glomeruli).
The glomeruli filter your blood, extracting fluid, waste and substances your body needs — sugar, amino acids, calcium and salts. These filtered materials then cross into tiny tubules, from which the bloodstream reabsorbs what the body can reuse. The rest is waste, which is excreted in your urine.
Although your kidneys are usually able to clear all the waste products your body produces, problems can occur if blood flow to your kidneys is disrupted, if the tubules or glomeruli become damaged or diseased, or if urine outflow is obstructed.
Progressive kidney damage most often results from a chronic illness over a period of years. Common causes include:
- Diabetes. Diabetes mellitus is a leading cause of chronic kidney failure in the United States. Chronic kidney failure is related to both type 1 and type 2 diabetes.
- High blood pressure (hypertension). Elevated blood pressure can damage the glomeruli and ultimately cause the nephrons containing damaged glomeruli to lose their ability to filter waste from your blood.
- Obstruction of urine flow. An enlarged prostate, kidney stones or tumors, or vesicoureteral reflux — a condition that results when urine backs up into your kidneys from your bladder — can block urine flow, increasing pressure in your kidneys and reducing their function.
- Kidney diseases. These include clusters of cysts in the kidneys (polycystic kidney disease), kidney infection (pyelonephritis) and inflammation of the glomeruli (glomerulonephritis), a condition that causes your kidneys to leak protein into your urine and damages nephrons.
- Kidney artery stenosis. This is a narrowing or blockage of the kidney (renal) artery before it enters your kidney, which impairs blood flow and leads to kidney damage.
- Toxins. Ongoing exposure to fuels and solvents, such as carbon tetrachloride, and lead — in lead-based paint, lead pipes, soldering materials, jewelry and even alcohol distilled in old car radiators — can lead to chronic kidney failure.
