Mayo Clinic Health Manager
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By Mayo Clinic staffSigns and symptoms may include some or many of the following:
- High blood pressure
- Decreased urine output or no urine output
- Darkly colored urine
- Anemia
- Nausea or vomiting
- Loss of appetite
- Sudden weight change
- A general sense of discomfort and unease (malaise)
- Fatigue and weakness
- Headaches that seem unrelated to any other cause
- Sleep problems
- Decreased mental sharpness
- Pain along your side or mid to lower back
- Muscle twitches and cramps
- Swelling of the feet and ankles
- Bloody or tarry stools, which could indicate bleeding in your intestinal tract
- Yellowish-brown cast to your skin
- Persistent itching
Chronic kidney failure can be difficult for you or your doctor to detect initially. Signs and symptoms are often nonspecific, meaning they can also be attributed to other illnesses. In addition, because your kidneys are highly adaptable and able to compensate for lost function, signs and symptoms of chronic kidney failure may not appear until irreversible damage has occurred.