Risk factorsBy Mayo Clinic staff
Krabbe disease is caused by a defective gene that must be inherited from both parents. But even if both parents have the defective gene, a child may not develop Krabbe disease.
If both parents are carriers of the defective gene for Krabbe disease, their offspring have a 25 percent risk of developing the disorder. If a child inherits the gene from only one parent, he or she will be a carrier but will never develop symptoms.
Krabbe disease occurs more often in people from Israel than in the population at large.
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