ComplicationsBy Mayo Clinic staff
Legionnaires' disease can lead to a number of life-threatening complications, including:
- Respiratory failure. This occurs when the lungs are no longer able to provide the body with enough oxygen or can't remove enough carbon dioxide from the blood.
- Septic shock. This occurs when a severe, sudden drop in blood pressure reduces blood flow to vital organs, especially the kidneys and brain. The heart tries to compensate by increasing the volume of blood pumped, but the extra workload eventually weakens the heart and reduces blood flow even further.
- Acute kidney failure. This is the sudden loss of your kidneys' ability to perform their main function — filtering waste material from your blood. When your kidneys fail, dangerous levels of fluid and waste accumulate in your body.
When not treated effectively and promptly, Legionnaires' disease may be fatal, especially if your immune system is weakened by disease or medications.
- Pedro-Botet ML, et al. Epidemiology and pathogenesis of Legionella infection. http://www.uptodate.com/home/index.html. Accessed Oct. 13, 2010.
- Patient facts: Learn more about Legionnaires' disease. Centers for Disease Control and Prevention. http://www.cdc.gov/legionella/patient_facts.htm. Accessed Oct. 13, 2010.
- Edelstein PH, et al. Legionella. In: Mandell GL, et al. Mandell, Douglas, and Bennett's Principles and Practices of Infectious Diseases. 7th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2010. http://www.mdconsult.com/books/linkTo?type=bookPage&isbn=978-0-443-06839-3&eid=4-u1.0-B978-0-443-06839-3..00232-0. Oct. 14, 2010.
- Pedro-Botet ML, et al. Treatment and prevention of legionella infection. http://www.uptodate.com/home/index.html. Accessed Oct. 13, 2010.
- Top 10 things every clinician needs to know about legionellosis. Centers for Disease Control and Prevention. http://www.cdc.gov/legionella/top10.htm. Accessed Oct. 13, 2010.
- Pedro-Botet ML, et al. Clinical manifestations and diagnosis of legionella infection. http://www.uptodate.com/home/index.html. Accessed Oct. 13, 2010.
- Neil K, et al. Increasing incidence of legionellosis in the United States, 1990-2005: Changing epidemiologic trends. Clinical Infectious Diseases. 2008;47:591.
- Nhu Nguyen TM, et al. A community-wide outbreak of Legionnaires disease linked to industrial cooling towers — How far can contaminated aerosols spread? Journal of Infectious Diseases. 2006;193:102.
- Centers for Disease Control and Prevention, et al. Legionnaires' disease associated with potting soil — California, Oregon, and Washington, May-June 2000. MMWR. 2000;49:777. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm4934a1.htm. Accessed Oct. 19, 2010.
- Legionellosis. World Health Organization. http://www.who.int/mediacentre/factsheets/fs285/en/index.html. Accessed Oct. 19, 2010.
- Sabria M, et al. Legionella infection. In: Fauci AS, et al. Harrison's Principles of Internal Medicine. 17th ed. New York, N.Y.: McGraw-Hill Medical; 2008. http://www.accessmedicine.com/content.aspx?aid=2871241. Accessed Oct. 13, 2010.
- Cunha BA. Legionnaires' disease: Clinical differentiation from typical and other atypical pneumonias. Infectious Disease Clinics of North America. 2010;24:73.