Leukoplakia

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Symptoms

By Mayo Clinic staff

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Photo of leukoplakia
Leukoplakia

Leukoplakia can have various appearances. Changes usually occur on your gums, the insides of your cheeks, the bottom of your mouth and, sometimes, your tongue. Leukoplakia may appear as:

  • White or grayish patches that can't be wiped away
  • Irregular or flat-textured areas
  • Thickened or hardened areas
  • Raised, red lesions (erythroplakia), which are more likely to show precancerous changes

A type of leukoplakia called hairy leukoplakia primarily affects people whose immune systems have been weakened by medications or disease, especially HIV/AIDS. Hairy leukoplakia causes fuzzy, white patches that resemble folds or ridges on the sides of your tongue. It's often mistaken for oral thrush — an infection marked by creamy white patches on the area that extends from the back of your throat to the top of your esophagus (pharynx) and the insides of the cheeks. Oral thrush also is common in people with HIV/AIDS.

When to see a doctor
Sometimes mouth sores can be annoying or painful without being harmful. But in other cases, mouth problems can indicate a more serious condition. For that reason, see your dentist if you have any of the following:

  • White plaques or sores in your mouth that don't heal on their own within seven to 10 days
  • Lumps or white, red or dark patches in your mouth
  • Persistent changes in the tissues of your mouth
References
  1. Goldstein BG, et al. Oral lesions. http://www.uptodate.com/home/index.html. Accessed July 29, 2010.
  2. Detecting oral cancer: A guide for health care professionals. National Institute of Dental and Craniofacial Research. http://www.nidcr.nih.gov/OralHealth/Topics/OralCancer/DetectingOralCancer.htm. Accessed Aug. 30, 2010.
  3. Sciubba JJ. Oral mucosal lesions. In: Cummings CW. Otolaryngology: Head and Neck Surgery. 5th ed. St. Louis, Mo.: Mosby; 2010. http://www.mdconsult.com/books/page.do?eid=4-u1.0-B978-0-323-05283-2..00092-6&isbn=978-0-323-05283-2&sid=1047132055&type=bookPage&sectionEid=4-u1.0-B978-0-323-05283-2..00092-6--s0045&uniqId=217089811-5#4-u1.0-B978-0-323-05283-2..00092-6--s0045 Accessed Sept.1, 2010. Accessed Sept. 1, 2010.
  4. Habif TP. Leukoplakia. In: Habif TP. Clinical Dermatology. 5th ed. St. Louis, Mo.: Mosby: 2010. http://www.mdconsult.com/books/page.do?eid=4-u1.0-B978-0-7234-3541-9..00030-4--s0565&isbn=978-0-7234-3541-9&sid=1047127391&type=bookPage&sectionEid=4-u1.0-B978-0-7234-3541-9..00030-4--s0565&uniqId=217089811-3#4-u1.0-B978-0-7234-3541-9..00030-4--s0565. Accessed Sept. 1, 2010.
  5. Reamy BV, et al. Common tongue conditions in primary care. American Family Physician. 2010;81:627.
DS00458 Nov. 2, 2010

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