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    Daniel K. Hall-Flavin, M.D.

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Question

Lexapro side effects: Is breast tenderness common?

I'm taking Lexapro, and my breasts seem unusually tender to the touch. For women, do Lexapro side effects include breast tenderness?

Answer

from Daniel K. Hall-Flavin, M.D.

Escitalopram (Lexapro) is a prescription drug commonly used to treat depression and generalized anxiety disorder. Breast tenderness isn't among the published Lexapro side effects, but some studies and unofficial reports have linked Lexapro and breast tenderness.

Lexapro may interfere with the normal processing of prolactin — a hormone that affects breast tissue. It's possible that this could lead to breast tenderness. Breast pain has been documented as a rare side effect of other antidepressants, including citalopram (Celexa), sertraline (Zoloft), venlafaxine (Effexor) and mirtazapine (Remeron). Some medications other than antidepressants also have been linked to breast tenderness.

Keep in mind, a number of other things can cause breast pain. Your doctor will consider any possible underlying causes for your symptoms. Your doctor may have you stop taking Lexapro for a period of time to see whether your breast tenderness improves. But don't change your dose or quit taking your antidepressant until you talk to your doctor. If your breast tenderness seems to be related to Lexapro, your doctor may recommend another antidepressant. In some cases, adding a medication specifically to relieve breast tenderness can help.

Next question
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References
  1. Lexapro (prescribing information). St. Louis, Mo.: Forest Laboratories; 2009. http://www.frx.com/pi/lexapro_pi.pdf. Accessed Oct. 28, 2010.
  2. Aggarwal A, et al. Escitalopram induced galactorrhoea: A case report. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2010;34:55.
  3. Smith RL, et al. Evaluation and management of breast pain. Mayo Clinic Proceedings. 2004;79:353.
  4. Golshan M, et al. Breast pain. http://www.uptodate.com/home/index.html. Accessed Oct. 28, 2010.
  5. Celexa (prescribing information). St. Louis, Mo.: Forest Laboratories; 2009. http://www.frx.com/pi/celexa_pi.pdf. Accessed Oct. 28, 2010.
  6. Zoloft (prescribing information). New York, N.Y.: Pfizer; 2010. http://media.pfizer.com/files/products/uspi_zoloft.pdf. Accessed Oct. 28, 2010.
  7. Effexor XR (prescribing Information). Philadelphia, Pa.: Wyeth Pharmaceuticals; 2009. http://www.pfizerpro.com/content/showlabeling.asp?id=100. Accessed Oct. 28, 2010.
  8. Remeron SolTab (prescribing information). Kenilworth, N.J.: Schering Corporation; 2010. https://www.spfiles.com/piremeronsoltab.pdf. Accessed Oct. 28, 2010.
AN01945 Dec. 7, 2010

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