Causes
By Mayo Clinic staffThe cause of lichen planus is unknown. The lesions that appear are the result of inflammation controlled by specific white blood cells called T lymphocytes. Normally, these cells are active at the site of disease or injury. Doctors and researchers don't know what prompts T lymphocytes to be activated in lichen planus. However, certain diseases, medical conditions or other factors may act as triggers of the inflammatory disorder in some people.
Factors that may act as triggers of lichen planus include:
- Hepatitis C infection
- Hepatitis B vaccine
- Certain types of flu vaccines
- Allergy causing agents (allergens)
- Tattoo pigments
- Nonsteroidal anti-inflammatory drugs, such as ibuprofen (Motrin, Advil, others) and naproxen (Aleve, others)
- Certain medications for heart disease, high blood pressure or arthritis
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- Lichen planus. American Academy of Dermatology. http://www.aad.org/public/publications/pamphlets/common_lichen.html. Accessed May 21, 2010.
- Lehman JS, et al. Lichen planus. International Journal of Dermatology. 2009;48:682.
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- Goldstein AT, et al. Vulvar lichen planus. Clinical Obstetrics and Gynecology. 2005;48:818.
- Psoriasis. National Institute of Arthritis and Musculoskeletal and Skin Diseases. http://www.niams.nih.gov/Health_Info/Psoriasis/default.asp. Accessed April 18, 2010.
- Glucocorticosteroid-induced osteoporosis. American College of Rheumatology. http://www.rheumatology.org/practice/clinical/patients/diseases_and_conditions/gi-osteoporosis.asp. Accessed April 15, 2010.
- Choonhakarn C, et al. The efficacy of aloe vera gel in the treatment of oral lichen planus: A randomized controlled trial. British Journal of Dermatology 2008;158:573.
- Rajar UD, et al. Efficacy of aloe vera gel in the treatment of vulval lichen planus. Journal of the College of Physicians and Surgeons - Pakistan. 2008;18:612.
- Gibson LE (expert opinion). Mayo Clinic, Rochester, Minn. May 31, 2010.

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