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By Mayo Clinic staffLichen planus of the skin is generally noncancerous (benign). It may clear up with treatment but can persist for months to years. People with long-term lesions of the mucous membranes are at greater risk of squamous cell carcinoma — a form of skin cancer. In these cases, a doctor may advise regular examinations to monitor any changes in the mucous membranes or the skin. It's also important to stop any tobacco use because tobacco raises your risk of squamous cell carcinoma.