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  • With Mayo Clinic nutritionist

    Katherine Zeratsky, R.D., L.D.

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Question

Lipovarin: An effective weight-loss supplement?

I'm thinking about trying a diet pill called Lipovarin. Can you tell me if it really works?

Answer

from Katherine Zeratsky, R.D., L.D.

There's no evidence that Lipovarin — a popular, nonprescription diet pill — promotes weight loss. In fact, this product may actually pose serious health risks.

Lipovarin contains the ingredient synephrine, a constituent of bitter orange. Synephrine is a stimulant similar to ephedrine, which is found in the herb ephedra. Safety concerns led to the removal of ephedra products from the U.S. market.

However, many manufacturers simply substituted synephrine in products that used to contain ephedra. These products, including Lipovarin, likely have the same serious health risks as ephedra products — including increased risk of stroke and heart attack.

Remember, there are no shortcuts to permanent weight loss. The foundation of every successful weight-loss program is a healthy diet and regular physical activity.

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References
  1. Lipovarin. Natural Medicines Comprehensive Database. http://www.naturaldatabase.com. Accessed Aug. 23, 2012.
  2. Bitter orange. Natural Medicines Comprehensive Database. http://www.naturaldatabase.com. Accessed Aug. 23, 2012.
  3. FDA issues regulation prohibiting sale of dietary supplements containing ephedrine alkaloids and reiterates its advice that consumers stop using these products. U.S. Food and Drug Administration.  http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2004/ucm108242.htm. Accessed Aug. 23, 2012.
  4. Hansen DK, et al. Physiological effects following administration of Citrus aurantium for 28 days in rats. Toxicology and Applied Pharmacology. 2012; 261:236.
  5. Zeratsky KA (expert opinion). Mayo Clinic, Rochester, Minn. Sept. 18, 2012.
AN01489 Dec. 11, 2012

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