Livedo reticularis: What causes it?

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    Lawrence E. Gibson, M.D.

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Question

Livedo reticularis: What causes it?

What causes livedo reticularis? Can it be a sign of an underlying disorder?

Answer

from Lawrence E. Gibson, M.D.

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Image of livedo reticularis Livedo reticularis

Livedo reticularis is a vascular condition characterized by a purplish mottled discoloration of the skin, usually on the legs. This discoloration is described as lacy or net-like in appearance. Livedo reticularis can be a normal condition that causes no symptoms and needs no treatment. But it can also be associated with serious underlying disorders, such as lupus, anti-phospholipid syndrome or Sneddon's syndrome. In addition, livedo reticularis may occur as a side effect of certain medications, such as hydroxyurea.

Livedo reticularis may be aggravated by cold exposure. If livedo reticularis is accompanied by pain or discomfort or if ulcers develop in the affected skin, further evaluation may be required. When necessary, treatment depends on the underlying cause, if known, and the severity of symptoms.

References
  1. Skin signs of immune, autoimmune and rheumatic diseases. In: Wolff K, et al. Fitzpatrick's Color Atlas & Synopsis of Clinical Dermatology. 5th ed. New York, N.Y.: McGraw-Hill Companies; 2005. http://www.accessmedicine.com/content.aspx?aID=751534. Accessed March 27, 2009.
  2. Hellmann DB, et al. Musculoskeletal & immunologic disorders. In: McPhee SJ, et al. Current Medical Diagnosis & Treatment. New York, N.Y.: McGraw-Hill Companies; 2009. http://www.accessmedicine.com/content.aspx?aID=10083. Accessed March 27, 2009.
  3. Chabner BA, et al. Antineoplastic agents. In: Brunton LL, et al. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 11th ed. New York, N.Y.: McGraw-Hill Companies; 2006. http://www.accessmedicine.com/content.aspx?aID=957513. Accessed April 13, 2009.
  4. Gibson LE (expert opinion). Mayo Clinic, Rochester, Minn. April 13, 2009.

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June 16, 2009

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