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Lung CT scan for cancer: Should you be screened?
Findings of a large clinical trial showed that lung CT scan screening reduced lung cancer deaths among smokers. Find out more.By Mayo Clinic staff
If you're a smoker or former smoker, you may worry about your risk of getting lung cancer or dying from it. A major study of heavy smokers, called the National Lung Screening Trial (NLST), compared lung CT scans and chest X-rays and found that getting a lung CT scan lowered the risk of dying of lung cancer. This is the first study to show lung cancer screening may save lives. However, not all study details have been released for careful review by doctors and scientists other than those who conducted the study. For that reason, most medical groups, including the American Cancer Society, don't yet recommend lung cancer screening to smokers and former smokers.
David Midthun, M.D., is a consultant in the Division of Pulmonary and Critical Care Medicine at Mayo Clinic, Rochester, Minn. He explains the results of the NLST study and the pros and cons of using lung CT scans for lung cancer screening.
Results of the National Lung Screening Trial suggest that smokers and former smokers might benefit from lung CT scan screening. Is that the case?
The result of the NLST is the first indication that any test can reduce deaths from lung cancer. The study involved more than 50,000 current and former heavy smokers — people who smoked the equivalent of a pack of cigarettes a day for 30 years — ages 55 to 74. Participants were randomized between low-dose spiral CT scan and chest X-ray at the start of the trial. They received annual screening tests for three years and then were followed for five years. The initial results of this trial revealed a reduction in lung cancer deaths with CT scan screening. The results showed 354 lung cancer deaths had occurred among those who had been screened with CT scan vs. 442 deaths among those who were screened with chest X-ray. That represents a 20.3 percent reduction with CT screening.
With some cancers, doctors encourage people to get regular screening. Will lung cancer be added to that list?
Currently, in most cases, screening for lung cancer is not recommended and not covered by Medicare or most insurance companies. However, the National Comprehensive Cancer Network (NCCN), the American College of Chest Physicians, the American Society of Clinical Oncology and the American Cancer Society have recommended screening for high-risk individuals ages 55 to 74 who have smoked a pack or more of cigarettes a day for 30 years or more, and who are still smoking or who quit less than 15 years ago. The NCCN also recommends screening for those 50 and older who have smoked a pack a day or more of cigarettes for 20 years or longer and have one additional risk factor for lung cancer. This could include a history of exposure to radon or occupational exposure to certain chemicals.
Screening for breast, cervical and colon cancers has been shown to reduce your risk of dying of these diseases when compared with those who don't get screened. Doctors recommend screening for these cancers because doing so has proved beneficial for a group of people in the study setting. It remains to be seen whether the NLST results regarding lung cancer will lead to changes in screening guidelines by the U.S. Preventive Services Task Force.Next page
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- Midthun DE (expert opinion). Mayo Clinic, Rochester, Minn. Jan. 31, 2011.
- National Lung Screening Trial: Questions and answers. National Cancer Institute. http://www.cancer.gov/newscenter/qa/2002/nlstqaQA. Accessed Jan. 20, 2011.
- National Lung Screening Trial research group. The National Lung Screening Trial: Overview and study design. Radiology. 2011;258:243.
- Mazzone PJ. Lung cancer screening: An update, discussion and look ahead. Current Oncology Reports. 2010;12:226.
- Ravenel JG, et al. Screening for lung cancer. American Journal of Roentgenology. 2008;190:755.
- Bach PB, et al. Screening for lung cancer: ACCP evidence-based clinical practice guidelines. 2nd ed. Chest. 2007;132:69.
- Lung cancer screening. Rockville, Md.: U.S. Preventive Services Task Force. http://www.uspreventiveservicestaskforce.org/3rduspstf/lungcancer/lungcanrs.htm. Accessed Jan. 21, 2011.
- Smith RA, et al. Cancer screening in the United States, 2009: A review of current American Cancer Society guidelines and issues in cancer screening. CA: A Cancer Journal for Clinicians. 2009;59:27.
- Smith-Bindman R, et al. Radiation dose associated with common computed tomography examinations and the lifetime attributable risk of cancer. Archives of Internal Medicine. 2009;169:2078.
- Lung cancer trial results show mortality benefit with low-dose CT. National Cancer Institute. http://www.cancer.gov/newscenter/pressreleases/NLSTresultsRelease. Accessed Jan. 21, 2011.
- Lung cancer screening. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). http://www.nccn.org/professionals/physician_gls/pdf/lung_screening.pdf. Accessed Dec. 19, 2011.
- Bach PB, et al. Benefits and harms of CT screening for lung cancer: A systematic review. Journal of the American Medical Association. In press. Accessed May 23, 2012.
- Wender R, et al. American Cancer Society lung cancer screening guidelines. CA: A Cancer Journal for Clinicians. In press. Accessed Feb. 20, 2013.