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Risk factors

By Mayo Clinic staff

Factors that may increase your risk of macular degeneration include:

  • Age. Your risk of macular degeneration increases as you age, especially after age 50. Macular degeneration is most common in people older than 65.
  • Family history of macular degeneration. If someone in your family had macular degeneration, you're more likely to develop the condition.
  • Race. Macular degeneration is more common in whites (Caucasians) than it is in other races.
  • Smoking. Smoking cigarettes increases your risk of macular degeneration.
  • Obesity. Being severely overweight increases the chance that early or intermediate macular degeneration will progress to the more severe form of the disease.
  • Unhealthy diet. A poor diet that includes few fruits and vegetables may increase the risk of macular degeneration.
  • Cardiovascular disease. If you have had diseases that affected your heart and blood vessels (cardiovascular disease), you may be at higher risk of macular degeneration.
  • Elevated cholesterol. Elevated cholesterol may be associated with a higher risk of macular degeneration.
References
  1. Facts about age-related macular degeneration. National Eye Institute. http://www.nei.nih.gov/health/maculardegen/armd_facts.asp. Accessed Aug. 29, 2012.
  2. What is age-related macular degeneration? American Academy of Ophthalmology. http://www.geteyesmart.org/eyesmart/diseases/amd.cfm. Accessed Aug. 29, 2012.
  3. Arroyo JG. Age-related macular degeneration: Epidemiology, etiology, and diagnosis. http://www.uptodate.com/index. Accessed Aug. 29, 2012.
  4. Macular degeneration symptoms. American Academy of Ophthalmology. http://www.geteyesmart.org/eyesmart/diseases/amd-symptoms.cfm. Accessed Aug. 29, 2012.
  5. Who is at risk for macular degeneration? American Academy of Ophthalmology. http://www.geteyesmart.org/eyesmart/diseases/amd-risk.cfm. Accessed Aug. 29, 2012.
  6. Arroyo JG. Age-related macular degeneration: Treatment and prevention. http://www.uptodate.com/index. Accessed Aug. 29, 2012.
  7. Macular degeneration diagnosis. American Academy of Ophthalmology. http://www.geteyesmart.org/eyesmart/diseases/amd-diagnosis.cfm. Accessed Aug. 29, 2012.
  8. Macular degeneration treatment. American Academy of Ophthalmology. http://www.geteyesmart.org/eyesmart/diseases/amd-treatment.cfm. Accessed Aug. 29, 2012.
  9. Primo SA. Implantable miniature telescope: Lessons learned. Optometry. 2010;81:86.
  10. Evans JR, et al. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration. Cochrane Database of Systematic Reviews. 2012;6:CD000253. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD000253.pub3/abstract. Accessed Aug. 29, 2012.
  11. Johnson EJ. Age-related macular degeneration and antioxidant vitamins: Recent findings. Current Opinion in Clinical Nutrition and Metabolic Care. 2010;13:28.
  12. Macular degeneration and low vision. American Academy of Ophthalmology. http://www.geteyesmart.org/eyesmart/diseases/amd-low-vision.cfm. Accessed Aug. 29, 2012.
  13. Chiu CJ, et al. Dietary carbohydrate and the progression of age-related macular degeneration: A prospective study from the Age-Related Eye Disease Study. The American Journal of Clinical Nutrition. 2007;86:1210.
  14. Low vision aids and low vision rehabilitation. American Academy of Ophthalmology. http://www.geteyesmart.org/eyesmart/diseases/low-vision-aids-rehabilitation.cfm. Accessed Sept. 4, 2012.
  15. Chong EWT, et al. Fat consumption and its association with age-related macular degeneration. Archives of Ophthalmology. 2009;127:674.
  16. Robertson DM (expert opinion). Mayo Clinic, Rochester, Minn. Oct. 2, 2012.
  17. Hughes DF. Charles Bonnet syndrome: A literature review into diagnostic criteria, treatment and implications for nursing practice. Journal of Psychiatric and Mental Health Nursing. In Press. Accessed Aug. 29, 2012.
DS00284 Nov. 20, 2012

© 1998-2013 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.com," "EmbodyHealth," "Enhance your life," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.

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