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Causes
By Mayo Clinic staff
Melanoma occurs when something goes awry in the melanin-producing cells (melanocytes) that give color to your skin. Normally, skin cells develop in a controlled and orderly way — healthy new cells push older cells toward your skin's surface, where they die and eventually are sloughed off. But when some cells develop DNA damage, new cells may begin to grow out of control and can eventually form a mass of cancerous cells.
Just what damages DNA in skin cells and how this leads to melanoma isn't clear. It's likely that a combination of factors, including environmental and genetic factors, causes melanoma. Still, doctors believe exposure to ultraviolet (UV) radiation from the sun and from tanning lamps and beds is the leading cause of melanoma.
UV light doesn't cause all melanomas, especially those that occur in places on your body that don't receive exposure to sunlight. This indicates that other factors may contribute to your risk of melanoma.
- What you need to know about melanoma. National Cancer Institute. http://www.cancer.gov/cancertopics/wyntk/melanoma/allpages. Accessed April 19, 2010.
- Lange JR, et al. Melanoma. In: Abeloff MD, et al. Abeloff's Clinical Oncology. 4th ed. Philadelphia, Pa.: Churchill Livingstone; 2008:1229.
- Melanoma: What it looks like. SkinCancerNet. http://www.skincarephysicians.com/skincancernet/melanoma.html. Accessed April 24, 2010.
- Albreski D, et al. Melanoma of the feet: Misdiagnosed and misunderstood. Clinics in Dermatology. 2009;27:556.
- Hussein MR. Extracutaneous malignant melanomas. Cancer Investigation. 2008;26:516.
- Elder DE. Dysplastic naevi: An update. Histopathology. 2010;56:112.
- Smith RA, et al. Cancer screening in the United States, 2009: A review of current American Cancer Society guidelines and issues in cancer screening. CA: A Cancer Journal for Clinicians. 2009;59:27.
- Skin examinations. SkinCancerNet. http://www.skincarephysicians.com/skincancernet/skin_examinations.html. Accessed April 24, 2010.
- Can melanoma be found early? American Cancer Society. http://www.cancer.org/docroot/CRI/content/CRI_2_4_3X_Can_melanoma_be_found_early_50.asp?sitearea=. Accessed April 24, 2010.
- Skin cancer screening. National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/screening/skin/healthprofessional/allpages. Accessed April 19, 2010.
- U.S. Preventive Services Task Force. Screening for skin cancer: U.S. Preventive Services Task Force Recommendation statement. Annals of Internal Medicine. 2009;150:188.
- Melanoma. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/PDF/melanoma.pdf. Accessed April 19, 2010.
- Melanoma treatment. National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/treatment/melanoma/healthprofessional/allpages. Accessed April 19, 2010.
- Lazovich D, et al. Indoor tanning and risk of melanoma: A case-control study in a highly exposed population. Cancer Epidemiology, Biomarkers & Prevention. 2010;19(6):1557. http://cebp.aacrjournals.org/content/early/2010/05/21/1055-9965.EPI-09-1249.full.pdf. Accessed May 27, 2010.
- Yervoy (prescribing information). Princeton, N.J.: Bristol-Myers Squibb; 2011. http://packageinserts.bms.com/pi/pi_yervoy.pdf. Accessed Dec. 19, 2011.
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