DefinitionBy Mayo Clinic staff
Membranous nephropathy is a disease in which the small blood vessels in the kidney (glomeruli), which filter wastes from the blood, become inflamed and thickened. As a result, proteins leak from the damaged blood vessels into the urine (proteinuria). For many, the loss of these proteins eventually causes some signs and symptoms known as nephrotic syndrome.
In mild cases, the disease often gets better on its own, without any treatment (remission). As the level of protein leakage increases, so does the risk of long-lasting damage. In many people (as many as 40 percent), the disease ultimately leads to kidney failure. Although there's no cure, treatments are available to slow the progress of the disease.
- Appel GB. Glomerular disorders and nephrotic syndromes. In: Goldman L, et al. Cecil Medicine. 24th ed. Philadelphia, Pa.: Saunders Elsevier; 2011. http://www.mdconsult.com/das/book/body/191371208-2/0/1492/0.html#. Accessed June 9, 2011.
- Fervenza FC, et al. Idiopathic membranous nephropathy: Diagnosis and treatment. Clinical Journal of the American Society of Nephrology. 2008;3:905.
- Swaminathan S, et al. Changing incidence of glomerular disease in Olmsted County, Minnesota: A 30-year renal biopsy study. Clinical Journal of the American Society of Nephrology. 2006;1:483.
- Beck LH, et al. Causes and diagnosis of membranous nephropathy. http://www.uptodate.com/contents/causes-and-diagnosis-of-membranous-nephropathy. Accessed June 9, 2011.
- Cattran D. Treatment of idiopathic membranous nephropathy. http://www.uptodate.com/contents/treatment-of-idiopathic-membranous-nephropathy. Accessed June 9, 2011.
- Coping effectively: A guide to living well with kidney failure. National Kidney Foundation. http://www.kidney.org/atoz/pdf/coping.pdf. Accessed July 18, 2011.
- What is proteinuria? National Kidney & Urologic Diseases Information Clearinghouse. http://kidney.niddk.nih.gov/kudiseases/pubs/proteinuria/. Accessed July 18, 2011.
- Fervenza FC, et al. Rituximab therapy in idiopathic membranous nephropathy: A 2-year study. Clinical Journal of the American Society of Nephrology. 2010;5:2188.
- Fervenza FC, et al. Rituximab in idiopathic membranous nephropathy. Kidney International. 2008;73:117.