The Mayo Clinic Diet Book, learn more

Free

E-newsletter

Subscribe to Housecall

Our weekly general interest
e-newsletter keeps you up to date on a wide variety of health topics.

Sign up now

Causes

By Mayo Clinic staff

Mental illnesses, in general, are thought to be caused by a variety of genetic and environmental factors:

  • Inherited traits. Mental illness is more common in people whose biological (blood) relatives also have a mental illness. Certain genes may increase your risk of developing a mental illness, and your life situation may trigger the actual mental illness.
  • Environmental exposures before birth. Exposure to viruses, toxins, alcohol or drugs while in the womb can sometimes be linked to mental illness.
  • Negative life experiences. Situations in your life, such as the loss of a loved one, financial problems and high stress, can play a role in triggering mental illness. So can an upbringing that leads to poor self-esteem or a history of sexual or physical abuse. Life experiences can lead to unhealthy patterns of thinking linked to mental illness, such as pessimism or distorted ways of thinking.
  • Brain chemistry. Biochemical changes in the brain are thought to affect mood and other aspects of mental health. Naturally occurring brain chemicals called neurotransmitters play a role in some mental illnesses. In some cases, hormonal imbalances affect mental health. It's thought that inherited traits, life experiences and biological factors can all affect brain chemistry linked to mental illnesses.
Risk factors Symptoms
References
  1. Psychotherapies. National Institute of Mental Health. http://www.nimh.nih.gov/health/topics/psychotherapies/index.shtml. Accessed July 24, 2012.
  2. Mental illness and the family: Recognizing warning signs and how to cope. Mental Health America. http://www.nmha.org/go/information/get-info/mi-and-the-family/recognizing-warning-signs-and-how-to-cope. Accessed July 23, 2012.
  3. Introduction. In: Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR. 4th ed. Arlington, Va.: American Psychiatric Association; 2000. http://www.psychiatryonline.com. Accessed June 13, 2012.
  4. Brain stimulation therapies. National Institute of Mental Health. http://www.nimh.nih.gov/health/topics/brain-stimulation-therapies/brain-stimulation-therapies.shtml. Accessed July 24, 2012.
  5. Mental health medications. National Institute of Mental Health. http://www.nimh.nih.gov/health/publications/mental-health-medications/index.shtml. Accessed July 24, 2012.
  6. Mind/body connection: How your emotions affect your health. American Academy of Family Physicians. http://familydoctor.org/online/famdocen/home/healthy/mental/782.printerview.html. Accessed July 23, 2012.
  7. Mental illness surveillance among U.S. adults. Centers for Disease Control. http://www.cdc.gov/mentalhealthsurveillance/fact_sheet.html. Accessed July 23, 2012.
  8. Treatment approaches for drug addiction. National Institute on Drug Abuse. http://www.drugabuse.gov/publications/drugfacts/treatment-approaches-drug-addiction. Accessed July 24, 2012.
  9. Understanding hospitalization for mental health. Depression and Bipolar Support Alliance. http://www.dbsalliance.org/site/Search?query=hospitalization&inc=10&x=0&y=0Accessed July 24, 2012.
  10. Salgado MF, et al. Family history of serious mental illness in bipolar I and bipolar II patients of the Mayo Bipolar Biobank. Biological Psychiatry. 2012;71:153S.
  11. Mental illness: Taking care of yourself. American Family Physician. 2008;78:363.
  12. Gold MS, et al. Psychosocial treatment of alcohol abuse and dependence. http://www.uptodate.com/index. Accessed June 2, 2012.
  13. Rackley S, et al. Depression in medically ill patients. Psychiatric Clinics of North America. 2012;35:231.
  14. Depression. National Institute of Mental Health. http://www.nimh.nih.gov/health/publications/depression/index.shtml. Accessed July 23, 2012.
  15. Sadock BJ, et al. Kaplan & Sadock's Comprehensive Textbook of Psychiatry. 9th ed. Philadephia, Pa.: Wolters Kluwer Health Lippincott Williams & Wilkins; 2009. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=booktext&D=books2&AN=01412563/9th_Edition/5&XPATH=/OVIDBOOK%5b1%5d/METADATA%5b1%5d/TBY%5b1%5d/EDITORS%5b1%5d. Accessed July 24, 2012.
  16. Li X, et al. Review of pharmacological treatment in mood disorders and future directions for drug development. Neuropsychopharmacology. 2012;37:77.
  17. McDowell AK, et al. Practical suicide-risk management for the busy primary care physician. Mayo Clinic Proceedings. 2011;86:792.
  18. Chamberlain AM, et al. Associations of preexisting depression and anxiety with hospitalization in patients with cardiovascular disease. Mayo Clinic Proceedings. 2011;86:1056.
  19. Index. In: Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR. 4th ed. Arlington, Va.: American Psychiatric Association; 2000. http://www.psychiatryonline.com. Accessed June 13, 2012.
  20. Understanding suicide: Fact sheet 2012. Centers for Disease Control and Prevention. http://www.cdc.gov/ViolencePrevention/pub/Suicide_factsheet.html. Accessed July 23, 2012.
  21. What is mental illness: Mental illness facts. National Alliance on Mental Illness. http://www.nami.org/template.cfm?section=about_mental_illness. Accessed July 23, 2012.
  22. Schreiber J, et al. Suicidal ideation and behavior in adults. http://www.uptodate.com/index. Accessed March 13, 2012.
  23. Kung S (expert opinion). Mayo Clinic Rochester, Minn. Aug. 7, 2012.
  24. Adjustment disorders. In: Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR. 4th ed. Arlington, Va.: American Psychiatric Association; 2000. http://www.psychiatryonline.com. Accessed Aug. 27, 2012.
DS01104 Sept. 15, 2012

© 1998-2013 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.com," "EmbodyHealth," "Enhance your life," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.

  • Reprints
  • Print

  • Share on:

  • Email

Advertisement


Text Size: smaller largerlarger