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Over-the-counter and prescription migraine medication options
By Mayo Clinic staffYou may have started treatment with over-the-counter medications, such as aspirin, ibuprofen (Advil, Motrin, others) or naproxen sodium (Aleve, others). These pain relievers, all classified as nonsteroidal anti-inflammatory drugs (NSAIDs), block the action of chemical messengers that cause pain.
NSAIDs or acetaminophen (Tylenol, others) may be enough to control the pain of mild to moderate migraines — especially when combined with caffeine. Some over-the-counter drugs are marketed specifically for migraines, such as the combination of acetaminophen, aspirin and caffeine (Excedrin Migraine) and extra-strength doses of ibuprofen (Motrin Migraine Pain and Advil Migraine Liqui-Gels).
Over-the-counter drugs have their drawbacks. Aspirin, ibuprofen, naproxen and similar drugs can cause stomach irritation. If you have a history of ulcers, gastritis or kidney disease, you may not be able to take these types of medicines. Acetaminophen may cause liver problems, particularly if you take excessive amounts or drink alcohol.
If you take an over-the-counter analgesic at the first sign of a migraine but still have disabling symptoms, your doctor may suggest a prescription-only version of a similar drug — such as diclofenac (Cataflam, Voltaren) or indomethacin (Indocin).
Triptans for migraine treatment Acute pain relief for migraine
