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Get StartedButalbital combinations for migraine treatment
By Mayo Clinic staffSometimes, medications that combine the sedative butalbital with aspirin or acetaminophen are prescribed to treat migraine attacks. Some combinations also include caffeine or codeine.
Butalbital combinations are likely to cause rebound headaches and withdrawal symptoms — especially if they're taken more than once a week. They're generally recommended only when a less problematic drug can't be used or isn't effective.
Common side effects include drowsiness, fatigue, nausea and lightheadedness. Feelings of euphoria or high spirits also are common, as well as impaired motor skills. Don't take butalbital combinations before driving or operating heavy machinery.
Due to the risk of addiction, butalbital combinations aren't recommended for people with a history of alcohol or drug abuse. If you're depressed, avoid butalbital combinations.
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