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  • With Mayo Clinic psychiatrist

    Daniel K. Hall-Flavin, M.D.

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Question

Mild depression: Are antidepressants effective?

I've heard antidepressants don't work for mild depression. Is that true?

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from Daniel K. Hall-Flavin, M.D.

Antidepressants don't work for everyone. For some people with mild depression, antidepressants seem to have little effect. However, for people with more severe depression, antidepressants often make a big difference.

Although antidepressants generally aren't as effective for mild depression, that doesn't mean that they never help. Depression affects each person differently, and each person responds to medications differently. Finding the right medication may take some trial and error.

If an antidepressant seems to ease your symptoms, it may be a good treatment choice for you. If you're taking an antidepressant, don't stop taking it without talking to your doctor.

For many people with mild depression, talk therapy (also called psychotherapy or psychological counseling) appears to be an effective treatment. Some people benefit from a combination of talk therapy and medications. Lifestyle changes — such as stress reduction and regular exercise — also can make a difference.

If you have signs and symptoms of depression, don't ignore them. Even mild depression can take a toll on your enjoyment of life, your performance at work or school, and your relationships with other people. And, left untreated, depression can get worse. Explore your treatment options with your doctor or mental health provider to figure out what's likely to work best to help you feel better again.

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References
  1. Vohringer PA, et al. Solving the antidepressant efficacy question: Effect sizes in major depressive disorder. Clinical Therapeutics. 2011;33:B49.
  2. Hegerl U, et al. Can effects of antidepressants in patients with mild depression be considered as clinically significant? Journal of Affective Disorders. 2012;138:183.
  3. Hegerl U, et al. Are antidepressants useful in the treatment of minor depression: A critical update of the current literature. Current Opinion in Psychiatry. 2012;25:1.
  4. Saeed SA, et al. Exercise, yoga and meditation for depressive and anxiety disorders. American Family Physician. 2010;8:981.
  5. Hall-Flavin DK (expert opinion). Mayo Clinic, Rochester, Minn. June 12, 2012.
  6. Kung S (expert opinion). Mayo Clinic, Rochester, Minn. June 20, 2012.
AN02074 July 3, 2012

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