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Complications
By Mayo Clinic staffSome people with monoclonal gammopathy of undetermined significance develop a more serious condition, such as multiple myeloma or other cancers or blood disorders.
Doctors can't definitively predict who will go on to develop a more serious condition, but they can determine who has the greatest risk. Your doctor takes into account several factors when determining your risk, including:
- The amount of M protein in your blood
- The type of M protein
- The amount of another small protein (free light chain) in your blood
Your risk of developing a more serious condition increases the longer you've had monoclonal gammopathy of undetermined significance. Also, the more risk factors you have, the higher your risk of developing a more serious condition.
Other complications associated with monoclonal gammopathy of undetermined significance include fractures and blood clots.
- Rajkumar SV. Diagnosis of monoclonal gammopathy of undetermined significance. http://www.uptodate.com/home. Accessed April 3, 2013.
- Rajkumar SV. Clinical course and management of monoclonal gammopathy of undetermined significance. http://www.uptodate.com/home. Accessed April 3, 2013.
- Blade J. Monoclonal gammopathies of undetermined significance. New England Journal of Medicine. 2006;355:2765.
- Rajkumar SV, et al. Advances in the diagnosis, classification, risk stratification, and management of monoclonal gammopathy of undetermined significance: Implications for recategorizing disease entities in the presence of evolving scientific evidence. Mayo Clinic Proceedings. 2010;85:945.
- Therneau TM. Incidence of monoclonal gammopathy of undetermined significance and estimation of duration before first clinical recognition. Mayo Clinic Proceedings. 2012;87:1071.
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