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Risk factors
By Mayo Clinic staffFactors that increase your risk of monoclonal gammopathy of undetermined significance include:
- Your age. The risk of monoclonal gammopathy of undetermined significance increases as you get older. About 1 percent of people age 25 and older and 5 percent of people age 70 and older have M protein in their blood. The highest incidence is among adults age 80 and older.
- Your race. Blacks are more likely to experience this condition than are whites.
- Your sex. Monoclonal gammopathy of undetermined significance is more common in men than it is in women.
- A family history. If other people in your family have monoclonal gammopathy of undetermined significance, your risk of developing the disorder may be higher.
- Your weight. People with a body mass index greater than 30 (a level that's considered obese) have a greater risk of developing monoclonal gammopathy of undetermined significance.
References
- Blade J. Monoclonal gammopathies of undetermined significance. New England Journal of Medicine. 2006;355:2765.
- Rajkumar SV, et al. Advances in the diagnosis, classification, risk stratification, and management of monoclonal gammopathy of undetermined significance: Implications for recategorizing disease entities in the presence of evolving scientific evidence. Mayo Clinic Proceedings. 2010;85:945.
- Rajkumar SV. Monoclonal gammopathy of undetermined significance. http://www.uptodate.com/home/index.html. Accessed Oct. 19, 2010.
- Monoclonal gammopathy of undetermined significance (MGUS). The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/print/sec11/ch144/ch144d.html. Accessed Oct. 21, 2010.
- Wadhera RK, et al. Prevalence of monoclonal gammopathy of undetermined significance: A systematic review. Mayo Clinic Proceedings. 2010;85:933.
- Landgren O, et al. Obesity is associated with an increased risk of monoclonal gammopathy of undetermined significance among black and white women. Blood. 2010;116:1056.
- Mikhael JR (expert opinion). Mayo Clinic, Scottsdale, Ariz. Nov. 12, 2010.
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