Monoclonal gammopathy of undetermined significance

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Risk factors

By Mayo Clinic staff

Factors that increase your risk of monoclonal gammopathy of undetermined significance include:

  • Your age. The risk of monoclonal gammopathy of undetermined significance increases as you get older. The highest incidence is among adults age 85 and older.
  • Your race. Blacks are more likely to experience this condition than are whites.
  • Your sex. Monoclonal gammopathy of undetermined significance is more common in men than it is in women.
  • A family history. If other people in your family have monoclonal gammopathy of undetermined significance, your risk of developing the disorder may be higher.
References
  1. Rajkumar SV. Diagnosis of monoclonal gammopathy of undetermined significance. http://www.uptodate.com/home. Accessed April 3, 2013.
  2. Rajkumar SV. Clinical course and management of monoclonal gammopathy of undetermined significance. http://www.uptodate.com/home. Accessed April 3, 2013.
  3. Blade J. Monoclonal gammopathies of undetermined significance. New England Journal of Medicine. 2006;355:2765.
  4. Rajkumar SV, et al. Advances in the diagnosis, classification, risk stratification, and management of monoclonal gammopathy of undetermined significance: Implications for recategorizing disease entities in the presence of evolving scientific evidence. Mayo Clinic Proceedings. 2010;85:945.
  5. Therneau TM. Incidence of monoclonal gammopathy of undetermined significance and estimation of duration before first clinical recognition. Mayo Clinic Proceedings. 2012;87:1071.
DS00870 May 17, 2013

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