Symptoms
By Mayo Clinic staffMonoclonal gammopathy of undetermined significance rarely causes signs or symptoms. The condition is usually detected by chance when you have a routine blood test for another problem. However, some people may experience nerve problems, such as numbness or tingling, associated with the abnormal protein.
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- Mikhael JR (expert opinion). Mayo Clinic, Scottsdale, Ariz. Nov. 12, 2010.

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