Symptoms
By Mayo Clinic staffMonoclonal gammopathy of undetermined significance rarely causes signs or symptoms. The condition is usually detected by chance when you have a routine blood test for another problem. However, some people may experience nerve problems, such as numbness or tingling, associated with the abnormal protein.
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- Rajkumar SV. Clinical course and management of monoclonal gammopathy of undetermined significance. http://www.uptodate.com/home. Accessed April 3, 2013.
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- Rajkumar SV, et al. Advances in the diagnosis, classification, risk stratification, and management of monoclonal gammopathy of undetermined significance: Implications for recategorizing disease entities in the presence of evolving scientific evidence. Mayo Clinic Proceedings. 2010;85:945.
- Therneau TM. Incidence of monoclonal gammopathy of undetermined significance and estimation of duration before first clinical recognition. Mayo Clinic Proceedings. 2012;87:1071.


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