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Tests and diagnosis
By Mayo Clinic staff
Physical exam
Your doctor may suspect mononucleosis based on your signs and symptoms and a physical examination. He or she will be looking for signs like swollen lymph nodes, tonsils, liver or spleen, and considering how these signs relate to the symptoms you describe.
Blood tests
- Antibody tests. If there's a need for additional confirmation, a monospot test may be done to check your blood for antibodies to the Epstein-Barr virus. This screening test gives results within a day. But it may not detect the infection during the first week of the illness. A different antibody test requires a longer result time, but can detect the disease even within the first week of symptoms.
- White blood cell count. Your doctor may use other blood tests to look for an elevated number of white blood cells (lymphocytes) or abnormal-looking lymphocytes. These blood tests won't confirm mononucleosis, but they may suggest it as a possibility.
References
- Epstein-Barr virus and infectious mononucleosis. Centers for Disease Control and Prevention. http://www.cdc.gov/ncidod/diseases/ebv.htm. Accessed April 27, 2010.
- Infectious mononucleosis. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/sec14/ch189/ch189f.html. Accessed April 27, 2010.
- Fort GG, et al. Mononucleosis. In: Ferri FF. Ferri's Clinical Advisor 2010. St. Louis, Mo.: Mosby; 2009. http://www.mdconsult.com/das/book/body/198193047-5/0/2088/420.html#4-u1.0-B978-0-323-05609-0..00022-8--sc0150_8624. Accessed April 27, 2010.
- Katz BZ. Epstein-Barr virus infections (mononucleosis and lymphoproliferative disorders). In: Long SS, et al., eds. Long: Principles and Practice of Pediatric Infectious Diseases. 3rd ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2008. http://www.mdconsult.com/das/book/body/198193047-5/0/1679/211.html?tocnode=55243816&fromURL=211.html#4-u1.0-B978-0-443-06687-0..50210-1_3825. Accessed April 27, 2010.
- Ross SM. An integrative approach to rhinosinusitis in children. Holistic Nursing Practice. 2009;23:302.
- Hoecker JL (expert opinion). Mayo Clinic, Rochester, Minn. April 29, 2010.
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