MSM for arthritis pain: Is it safe?

Are there any adverse effects from long-term use of MSM for arthritis pain?

- Marilyn / Canada

Mayo Clinic rheumatologist April Chang-Miller, M.D., and colleagues answer select questions from readers.

Answer

Few studies have examined the long-term effects of the dietary supplement called methylsulfonylmethane (MSM). One study suggested that it's safe to take MSM for up to 12 weeks. But further research is needed to assess its safety for long-term use.

There's no conclusive evidence that MSM is effective in reducing arthritis pain. Two small studies have suggested that MSM may reduce joint pain in people with osteoarthritis. Side effects of MSM may include stomach upset, diarrhea and headache.

Although there is great interest in using MSM to treat a variety of conditions, including arthritis, more research is needed to determine its potential benefits and risks.