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  • With Mayo Clinic neurologist

    Jerry W. Swanson, M.D.

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Question

Multiple sclerosis treatment: Is combination therapy effective?

What can you tell me about combination therapy as a multiple sclerosis treatment option? Is it effective?

Answer

from Jerry W. Swanson, M.D.

Combination therapy most often refers to the use of two or more medications to treat a single disease. Scientists are studying the potential benefits of combination drug therapy in multiple sclerosis treatment.

Interferon beta-1a (Avonex, Rebif) and glatiramer (Copaxone) are two drugs currently used to treat relapsing remitting multiple sclerosis (MS). Each drug works in a different way, and both are generally considered mildly to moderately effective in reducing MS symptoms.

To determine whether these two drugs used in combination may provide a greater benefit than either drug used alone, a randomized, double-blind, multicenter study is under way. The study — which addresses the safety as well as the effectiveness of the drug combination — began in 2005. Results are expected in 2012.

Until study results are released, it's unclear what role — if any — combination drug therapy may play in routine multiple sclerosis treatment.

Next question
Vitamin D and MS: Is there any connection?
References
  1. Combination therapy in patients with relapsing-remitting multiple sclerosis. ClinicalTrials.gov. http://clinicaltrials.gov/ct2/show/NCT00211887?term=multiple+sclerosis&intr=avonex%2C+copaxone&rank=4. Accessed Aug. 20. 2008.

AN01482

Oct. 30, 2008

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