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Symptoms
By Mayo Clinic staffSigns and symptoms of multiple sclerosis vary widely, depending on the location of affected nerve fibers. Multiple sclerosis signs and symptoms may include:
- Numbness or weakness in one or more limbs, which typically occurs on one side of your body at a time or the bottom half of your body
- Partial or complete loss of vision, usually in one eye at a time, often with pain during eye movement (optic neuritis)
- Double vision or blurring of vision
- Tingling or pain in parts of your body
- Electric-shock sensations that occur with certain head movements
- Tremor, lack of coordination or unsteady gait
- Fatigue
- Dizziness
Most people with multiple sclerosis, particularly in the beginning stages of the disease, experience relapses of symptoms, which are followed by periods of complete or partial remission. Signs and symptoms of multiple sclerosis often are triggered or worsened by an increase in body temperature.
- Olek MJ. Epidemiology, risk factors and clinical features of multiple sclerosis in adults. http://www.uptodate.com/home/index.html. Accessed Sept. 29, 2010.
- Olek MJ. Treatment of relapsing-remitting multiple sclerosis in adults. http://www.uptodate.com/home/index.html. Accessed Sept. 29, 2010.
- Multiple sclerosis: Hope through research. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/multiple_sclerosis/detail_multiple_sclerosis.htm. Accessed Oct. 14, 2010.
- Neurological diagnostic tests and procedures. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/misc/diagnostic_tests.htm. Accessed Oct. 14, 2010.
- Burt RK, et al. Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study. Lancet Neurology. 2009;8:244.
- Foley F, et al. Taming stress in multiple sclerosis. National Multiple Sclerosis Society. http://www.nationalmssociety.org/search-results/index.aspx?q=stress&x=0&y=0&start=0&num=20. Accessed Oct. 15. 2010.
- Harmon M. Exercise as part of everyday life. National Multiple Sclerosis Society. http://www.nationalmssociety.org/search-results/index.aspx?q=exercise&sitesearch=&x=0&y=0&start=0&num=20. Accessed Oct. 14, 2010.
- Medication guide: Gilenya. U.S. Food and Drug Administration. http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Label_ApprovalHistory. Accessed Oct. 20, 2010.
- Lucchinetti CF (expert opinion). Mayo Clinic, Rochester, Minn. Oct. 18, 2010.
- Baclofen. Micromedex Healthcare Series. http://www.micromedex.com. Accessed Nov. 23, 2010.
- Tizanidine hydrochloride. Micromedex Healthcare Series. http://www.micromedex.com. Accessed Nov. 23, 2010.
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